外周血中循环肿瘤核酸检测的研究进展  

Progress of circulating tumor DNA detection in cancer

作　　者：赵明[1] 王可敬[1] 赏金标[1] 郑伟慧[1] Zhao Ming;Wang Kejing;Shang Jinbiao;Zheng Weihui.(Department of Head and Neck Surgery, Zhejiang Tumor Hospital, Hangzhou, Zhejiang 310022, China)

机构地区：[1]浙江省肿瘤医院头颈外科,浙江省杭州310022

出　　处：《中国基层医药》2018年第11期1495-1496,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医药卫生科技计划项目（2018260728）

摘　　要：外周血循环肿瘤DNA（ctDNA）是指肿瘤细胞体细胞DNA经脱落或者当细胞凋亡后释放进入血循环系统的一类DNA。ctDNA是一种特征性的肿瘤生物标志物，被称为＂液体活检＂技术。可以反映肿瘤的侵袭与转移，能监测肿瘤的疗效和预后的评估。目前的研究主要集中在研究相对成熟的乳腺癌、肺癌等病种。该研究对ctDNA检查技术的发展及其国内外目前研究现状进行综述。Peripheral blood circulating tumor DNA （ctDNA） is a kind of DNA that is released.into the blood circulation system after the tumor cell somatic cell DNA is exfoliated or when the cell apoptosis is released, ctDNA is a characteristic tumor biomarker,known as ＂liquid biopsy＂. It can reflect the invasion and metastasis of the tumor, and can monitor the effect and prognosis of the tumor. The current research is mainly focused on relatively mature breast cancer,lung cancer and other diseases. In this study, the development of ctDNA inspection technology and its current research status at home and abroad are reviewed.

关 键 词：DNA  肿瘤 血液循环 癌症早期检测 综述文献(主题) 

分 类 号：R730.43[医药卫生—肿瘤]