帕金森病合并异动症患者血浆维生素B_(12)水平的相关因素研究  

Related factor study on plasma vitamin B_(12) in patients with Parkinson's disease and dyskinesias

作　　者：王丽[1] 王小平[1] 李庭毅[1] WANG Li;WANG Xiaoping;LI Tingyi(Department of Neurology, Central Hospital of Xiaogan,Xiaogan 432000,Chin)

机构地区：[1]孝感市中心医院神经内科,湖北孝感432000

出　　处：《中国实用神经疾病杂志》2018年第9期961-965,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察维生素B_(12)(vitamin B_(12),VitB_(12))、叶酸(folic acid,FA)、同型半胱氨酸(homocysteine,Hcy)在帕金森异动症患者血浆中的变化,分析VitB_(12)水平变化的相关因素。方法237例帕金森病患者根据异动症定义分为异动症组(63例)和非异动症组(174例),比较2组血浆VitB_(12)、FA、Hcy水平,将差异有统计学意义的指标选出,异动症组按性别、年龄、起病年龄、病程、左旋多巴使用时间、日多巴总量、H-Y分期分组,并进行组间对比。结果异动症组血浆Hcy、FA水平与非异动症组比较差异无统计学意义(P>0.05)。异动症组血浆VitB_(12)水平与非异动症组比较差异有统计学意义(P<0.01)。异动症组中不同性别、年龄、起病年龄、病程、使用多巴时间及H-Y分期患者血浆维生素B_(12)水平无明显差异(P>0.05),而不同日多巴总量患者血浆VitB_(12)水平差异有统计学意义(P<0.05),且日多巴总量越大,血浆VitB_(12)水平越低。结论帕金森病异动症患者血浆VitB_(12)水平明显降低,影响异动症患者血浆VitB_(12)变化的因素为日多巴总量。Objective To observe the changes of plasma levels of vitamin B12 ,folic acid,homocysteine and the relevant factor of causing change in patients with Parkinson’s disease and dyskinesias.Methods 237patients of Parkinson’s disease were divided into dyskinesias（63patients）and non-dyskinesias（174patients）according to the clinical definition of dyskinesias.Plasma levels of vitamin B12 ,folic acid,homocysteine in two groups were compared.Then,we elected discrepant indicator and contrasted its difference in the different gender,age,age onset,duration,the cumulative time of medication of levodopa,daily volume dose of levodopa and Hoehn-Yahr staging in dyskinesias.Results The difference of the plasma levels of Hcy and FA of dyskinesias and nondyskinesias wasn’t statistical significance（P〉0.05）.The difference of the plasma level of vitamin B12 of dyskinesias and non-dyskinesias was statistical significance（P〈0.01）.The plasma level of vitamin B12 of dyskinesias weren’t statistically significant difference in terms of gender,age,age onset,duration,the cumulative time of medication of levodopa,and Hoehn-Yahr staging（P〉0.05）.The plasma level of vitamin B12 of dyskinesias related to the daily volume dose of levodopa was statistical significance（P〈0.05）.The bigger daily volume dose of levodopa,the lower plasma level of vitamin B12 .Conclusion The plasma level of vitamin B12 of dyskinesias is lower.The factor affecting the plasma level of vitamin B12 of dyskinesiasis the daily volume dose of levodopa.

关 键 词：帕金森病 异动症 维生素B12 叶酸 同型半胱氨酸 左旋多巴 

分 类 号：R742.5[医药卫生—神经病学与精神病学]