输卵管绝育术与子宫内膜增生及子宫内膜癌的关系  

Correlation of tubal sterilization with endometrial hyperplasia and endometrial carcinoma

作　　者：宋广叶 宋志宇 韩海琼[3] 霍月红[4] Song Gaangye;Song Zhiyu;Hart Haiqiong;Huo Yuehong(Department of Gynecology, the First People＂ s Hospital of Datong, Datong 037000, Chin;Department Pathology, the Health School of Datong, Datong 037000, Chin;Department of Gynecology, Shanxi Provincial Cancer Hospital, Taiyuan 030013,China;Department of Internal Medicine, the Fifth People＇s Hospital of Datong, Datong 037001, Chin)

机构地区：[1]大同市第一人民医院妇科,037000 [2]大同市卫生学校病理科,037004 [3]山西省肿瘤医院妇科,太原030013 [4]大同市第五人民医院内科,037006

出　　处：《肿瘤研究与临床》2018年第5期324-326,共3页Cancer Research and Clinic

摘　　要：目的探讨输卵管绝育术与子宫内膜增生及子宫内膜癌的关系。方法回顾性分析2008年1月至2017年1月山西省大同地区4 987例接受诊断性刮宫者的临床资料，按照病理类型分为子宫内膜异常组2 891例（单纯性增生、复杂性增生、不典型增生、子宫内膜癌）和子宫内膜正常组2 096例（增生期子宫内膜、分泌期子宫内膜、萎缩性子宫内膜），对输卵管绝育术与子宫内膜增生和子宫内膜癌的关系进行分析。结果单因素分析结果显示：输卵管绝育术后患者子宫内膜异常与年龄、文化程度、是否绝育、绝育年限和绝经年限有关，差异有统计学意义（χ2值分别为36.47、15.05、33.11、34.50、5.19，均P〈0.05），其余变量差异均无统计学意义（均P〉0.05）。多因素Logistic回归分析结果显示：年龄≥60岁（OR=5.64，95% CI 1.42-16.08，P=0.012）、绝育（OR=4.76，95% CI 1.31-12.69，P=0.015）、绝育年限≥10年（OR=15.58，95% CI 2.05-118.54，P=0.008）是导致患者子宫内膜异常的高危因素。结论输卵管绝育术是导致子宫内膜增生和子宫内膜癌发生的高危因素，对该类手术后患者应加强防癌普查。ObjectiveTo investigate the relationship between tubal sterilization and endometrial hyperplasia and endometrial cancer.MethodsThe clinical data of 4 987 peoples with diagnostic curettage in Datong, Shanxi Province from January 2008 to January 2017 were retrospectively analyzed. According to the pathological type, 2 891 cases were in abnormal endometrium group （simple hyperplasia, complex hyperplasia, and atypical hyperplasia, endometrial cancer） （experimental group） and 2 096 cases were in normal endometrium group （proliferative endometrium, secretory endometrium, atrophic endometrium） （control group）. The relationship between tubal sterilization and endometrial hyperplasia and endometrial cancer was analyzed.ResultsThe proportion of age, education level, sterilization, duration of sterilization and menopausal years were significantly different between the two groups （χ2 values were 36.47, 15.05, 33.11, 34.50, 5.19, all P 〈 0.05）. There was no significant difference in the other variables （all P 〉 0.05）. Multivariate Logistic regression analysis showed that age ≥60 years （OR=5.64, 95% CI 1.42-16.08, P=0.012）, sterilization （OR=4.76, 95% CI 1.31-12.69, P=0.015）, duration of sterilization ≥10 years （OR=15.58, 95% CI 2.05-118.54, P=0.008） were high risk factors for endometrial abnormalities.ConclusionsTubal sterilization is a risk factor for the development of endometrial hyperplasia and endometrial cancer. The postoperative patients should be strengthened anti-cancer census.

关 键 词：绝育  输卵管 子宫内膜肿瘤 子宫内膜增生 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]