肝失疏泄情志病证结合研究新思考  

New ideas on Combining Liver Qi Failing to Flow Freely Syndrome and Emotional Disorders

作　　者：史亚飞[1] 张荣[2] 杨蕾[2] SHI Yafeil;ZHANG Rong;YANG Lei(Basic Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Clinical Pharmacology Institute of Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学基础医学院,广东广州510006 [2]广州中医药大学临床药理研究所,广东广州510006

出　　处：《山东中医药大学学报》2018年第3期192-195,共4页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81573912);广东省自然科学基金项目(编号:2015A030313356);广州中医药大学高水平大学建设资助项目(编号:A1-AFD018171Z11032)

摘　　要：情志内伤肝失疏泄可作为基本证候创新研究的重要证型。积极适应证候的动态演变性,关注情志内伤致病因素的复杂性、早期性、潜伏性,早期应激效应成为深化情志内伤肝失疏泄病证研究新途径。肝常有余是小儿情志变化的病理生理基础,基于小儿肝常有余理论,使生命早期应激过程中的模型复制与病程模拟可更加合理模拟情志内伤肝失疏泄病证。进一步关注生命早期负性应激的重要作用,并与成年后应激有机结合,将有助于动态观察情志内伤肝失疏泄病证变化,阐释早期应激下情志内伤潜伏期或缓解期病机,研究青少期应激中医药有效干预手段,实现肝失疏泄基本证候研究新突破。五羟色胺（5-HT）系统在青少期即已达到成熟且一直维持至成年,可以为青少期及成年后两个阶段提供研究靶点。Emotional internal injuries and liver qi failing to flow freely can be used as an important syndrome of innovative syndrome research. Actively adapt to the dynamic evolution of syndromes ,pay attention to the complexity,early stage and latent features of pathogenic factors in emotional disorders. Early stress effects become the new method for deepening study on emotional internal injuries and liver qi failing to flow freely. Liver being often in superabundance is the pathophysiologial basis for the emotional changes in children. Based on the theory of liver being often in superabundance,the model duplication and duration simulation in early life stress can be more reasonable to simulate the emotional internal injuries and liver qi failing to flow freely. To pay more attention to the important role of negative stress in early life and organically combine with stress in adulthood will help to observe the changes of emotional internal injuries and liver qi failing to flow freely,to explain the pathogenesis during early stress in the latent or remission period,to study the effective methods in intervening adolescent stress in traditional Chinese medicine and to achieve a new breakthrough in the study of basic syndromes of liver qi failing to flow freely. The 5-hydrox-ytryptamine（5-HT） system has reached maturity in the adolescence and remains in the adulthood,providing research targets for both the adolescence and adulthood.

关 键 词：肝失疏泄 情志病证 早期应激 思路 

分 类 号：R2-03[医药卫生—中医学]