肝细胞生长因子浓度变化与动脉瘤性蛛网膜下腔出血病人预后的关系  

Association between hepatocyte growth factor levels and outcomes of the patients with aneurysmal subarachnoid hemorrhage

作　　者：梁仔 徐力[2] 林国庆 Liang Zai;Xu Li;Lin Guoqing(Department ofNeurosurgery, Lianjiang People＇s Hospital, Affiliated Hospital of Guangdong Medical University, Lianjiang, Guangdong 524400, China;Department of Neurosurgery, Central People＇s Hospital ofZhanjiang, Zhanjiang, Guangdong 524001, China)

机构地区：[1]广东医科大学附属廉江市人民医院神经外科,廉江524400 [2]湛江中心人民医院神经外科,524001

出　　处：《中国微侵袭神经外科杂志》2018年第5期208-210,共3页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的观察动脉瘤性蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)病人血液中肝细胞生长因子(hepatocyte growth factor,HGF)浓度变化及其与病人预后的关系。方法回顾性分析56例aSAH病人(aSAH组)出血12 h、24 h及72 h的HGF、白细胞介素-10(interleukin-10,IL-10)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)浓度变化;并以未破裂颅内动脉瘤病人(阴性对照组,n=50)及健康志愿者(正常对照组,n=50)作为对照。随访aSAH病人出院3个月后GOS,对恢复情况进行评价。结果与正常对照组和阴性对照组相比,aSAH组病人出血12 h时HGF、IL-10及TNF-α浓度明显升高(均P<0.05)。56例aSAH病人出院3个月均存活,根据GOS分为预后好组(GOS 4~5分)和预后差组(GOS 1~3分)。aSAH后12 h、24 h及72 h时HGF浓度,预后好组均高于预后差组(P<0.05);aSAH后12 h及24 h时,预后好组的IL-10浓度高于预后差组(P<0.05),而TNF-α浓度低于预后差组(P<0.05)。结论 aSAH 12 h时,病人血液中HGF、IL-10及TNF-α浓度明显升高,HGF浓度越高提示aSAH病人预后好,可能与HGF抑制炎症反应作用有关。Objective To observe the association between hepatocyte growth factor（HGF） levels and outcomes of the patients with aneurysmal subarachnoid hemorrhage（aSAH）. Methods The clinical data of 56 aSAH patients（aSAH group） were analyzed retrospectively.The HGF, interleukin-10（IL-10） and tumor necrosis factor-α（TNF-α） levels were measured at 12, 24 and 72 h post-hemorrhage. There were 50 unruptured aneurysm patients（negative control group） and 50 healthy volunteer（normal control group） as comparison. After a3-month follow-up period, patient outcomes were evaluated by the Glasgow Outcome Score（GOS）. Results Compared to negative control group and normal control group, the levels of HGF, IL-10 and TNF-α at 12 h post-hemorrhage were higher in aSAH group（all P〈0.05）. All 56 aSAH patients survived for 3 months after discharge. According to GOS, 56 aSAH patients were divided into good prognosis group（GOS 4 to 5 points） and poor prognosis group（GOS 1 to 3 points）. The HGF levels at 12, 24, and 72 h post-hemorrhage in good prognosis group were higher than poor prognosis group（P〈0.05）. The IL-10 levels were higher and TNF-α levels were lower at12 h and 24 h post-hemorrhage in good prognosis group than poor prognosis group（all P〈0.05）. Conclusions The levels of HGF,IL-10 and TNF-α are high in aSAH patients at 12 h post-hemorrhage. A high HGF level is associated with a good functional outcome after aSAH, which may be associated with anti-inflammatory effects of HGF.

关 键 词：蛛网膜下腔出血 肝细胞生长因子 白细胞介素-10 炎症反应 

分 类 号：R743-35[医药卫生—神经病学与精神病学]