芪棱汤联合前列地尔对动脉粥样硬化性脑梗死患者血脂水平及神经功能的影响研究  

Effect of Qileng Decoction Combined with Alprostadil on Blood Lipid Levels and Neurological Function for Patients with Atherosclerotic Cerebral Infarction

作　　者：周茂平[1] ZHOU Maoping(The First People＇s Hospital of Guangyuan City （ Guangyuan Sichuan 628000, China)

机构地区：[1]广元市第一人民医院,四川广元628000

出　　处：《四川中医》2018年第5期134-136,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察芪棱汤联合前列地尔对动脉粥样硬化性脑梗死患者血脂水平及神经功能的影响。方法:利用随机数字表法将我院收治的90例动脉粥样硬化性脑梗死病例分为两组,每组45例,两组均接受脑梗死常规治疗方案,对照组给予前列地尔,观察组基于对照组予以芪棱汤,比较两组治疗前后中医症候积分、血液流变学指标、血清内脂素、血脂水平、神经功能缺损(NIHSS)评分、不良反应。结果:观察组治疗后各中医症候积分、全血黏度(包括高切与低切)、红细胞聚集指数、红细胞压积、血沉及纤维蛋白原水平明显低于对照组(P<0.05),红细胞变形指数明显高于对照组(P<0.05);观察组血清内脂素、LDL-C、TC、TG水平、NIHSS评分均明显低于对照组(P<0.05);观察组治疗过程中不良反应总发生率(17.78%)与对照组(13.33%)比较无显著差异(P>0.05)。结论:芪棱汤联合前列地尔可有效缓解动脉粥样硬化性脑梗死患者临床症状,改善血脂与血液流变学指标水平,促进神经缺损功能恢复,且不良反应少。Objective： To observe the effect of Qileng Decoction combined with alprostadil on blood lipid levels and neurological function in patients with atherosclerotic cerebral infarction. Methods： 90 patients with atherosclerotic cerebral infarction in the hospital were divided into two groups by the random number table method,45 cases in each group. The two groups were given routine treatment for cerebral infarction. The controlled group was treated with alprostadil while the observation group was treated with Qileng Decoction combined with alprostadil. The TCM symptom scores,hemorheological indexes,levels of serum visfatin and blood lipids,neurological impairment（ NIHSS） scores and adverse reactions were compared between the two groups. Results： After treatment,the TCM symptom scores,whole blood viscosity（ high shear and low shear）,erythrocyte aggregation index,hematocrit,erythrocyte sedimentation rate and fibrinogen levels in the observation group were significantly lower than those in the controlled group（ P〈0. 05）,while the erythrocyte deformation index was significantly higher than that in the controlled group（ P〈0. 05）. The levels of serum visfatin,LDL-C,TC and TG and NIHSS score in the observation group were significantly lower than those in the controlled group（ P〈0. 05）. There was no significant difference in the total incidence of adverse reactions between the two groups during treatment（ 17. 78% vs 13. 33%）（ P〉 0. 05）. Conclusion： Qileng Decoction combined with alprostadil can effectively relieve the clinical symptoms of atherosclerotic cerebral infarction,improve the levels of blood lipids and hemorheological indexes and promote the recovery of neurological function,with few adverse reactions.

关 键 词：芪棱汤 前列地尔 动脉粥样硬化性脑梗死 血脂 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]