半夏泻心汤联合泮托拉唑治疗消化性溃疡临床研究及对血清NO、IL-2、IL-6影响  

Curative Efficacy of Banxia Xiexin Decoction Combined with Pantoprazole in the Treatment of Peptic Ulcer and Its Effects on Serum NO,IL-2 and IL-6

作　　者：吴大威[1] 范穗强 杨玉双 崔清志 王静 刘立奇 WU Dawei;FAN Suiqiang;YANG Yushuang;CUI Qingzhi;WANG Jing;LIU Liqi(203rd Hospital of the PLA, Qigihar 161000, Heilongjiang, China;The First Affiliated Hospital of Guangdong Medical University, Guangzhou 510000, Guangdong, China)

机构地区：[1]解放军第203医院,黑龙江齐齐哈尔161000 [2]广东药科大学附属第一医院,广东广州510000

出　　处：《辽宁中医药大学学报》2018年第4期206-209,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的：探讨半夏泻心汤联合泮托拉唑治疗消化性溃疡的疗效及对血清一氧化氮（NO）、白介素（IL）-2、IL-6的影响。方法：选择2014年12月—2016年12月我院接诊的104例消化道溃疡患者作为本研究对象,通过随机数字表法分为观察组（n=52）和对照组（n=52）,对照组使用泮托拉唑钠肠溶片治疗,观察组联合半夏泻心汤治疗,治疗期间叮嘱患者注意饮食,均连续治疗2周。比较两组治疗前后血清NO、IL-2、IL-6及临床症状积分的变化,并比较Hp清除率、临床疗效及不良反应。结果：治疗后,两组血清NO、IL-6较治疗前均显著降低,血清IL-2显著升高（P〈0.05）;观察组血清NO、IL-6明显比对照组低,血清IL-2明显高于对照组（P〈0.05）;治疗后,两组上腹痛、反酸嗳气、烧心症状积分较治疗前均显著降低（P〈0.05）,观察组上腹痛、反酸嗳气、烧心症状积分均明显比对照组低（P〈0.05）;观察组Hp清除率明显高于对照组[82.69%（43/52）vs 57.69%（30/52）]（P〈0.05）;观察组临床疗效总有效率明显高于对照组[90.38%（47/52）vs 69.23%（36/52）]（P〈0.05）;两组不良反应发生率无显著差异（P〉0.05）。结论：在消化性溃疡患者中使用半夏泻心汤联合泮托拉唑效果显著,可有效缓解临床症状,促进黏膜愈合,其内在机制可能和调节血清NO、IL-2、IL-6的表达相关。Objective：To study curative efficacy of Banxia Xiexin Decoction combined with pantoprazole in treatment of peptic ulcer and its effects on serum nitric oxide（NO）,interleukin（IL）-2 and IL-6. Methods：104 patients of peptic ulcer who received therapy from December 2014 to December 2016 in our hospital were selected as research objects. According to random number table,those patients were divided into the observation group（n=52）and the control group（n=52）. The control group was treated with pantoprazole,while the observation group was combined with Banxia Xiexin Decoction,during treatment,patients were advised to pay attention to diet,and they were treated continuously for 2 weeks. The changes of serum NO,IL-2,IL-6 and clinical symptom scores were compared between the two groups before and after treatment,and the Hp clearance rate,clinical efficacy and adverse reactions were compared. Results：After treatment,the serum NO and IL-6 of the two groups were significantly lower than those before treatment,and the serum IL-2 levels increased significantly（P〈0.05）,the serum NO and IL-6 in the observation group were significantly lower than that of the control group,and the serum IL-2 was significantly higher than that of the control group（P〈0.05）;after treatment,upper abdominal pain,heartburn,acid regurgitation and belching symptom scores of the two groups were significantly lower than before treatment（P〈0.05）,the upper abdominal pain,heartburn,acid regurgitation and belching symptoms in the observation group were significantly lower than the control group（P〈0.05）;the Hp clearance rate in the observation group was significantly lower than that of the control group[82.69%（43/52）vs57.69%（30/52）]（P〈0.05）;the total effective rate in the observation group was significantly higher than that of the control group[90.38%（47/52）vs69.23%（36/52）]（P〈0.05）;there was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）.

关 键 词：消化道溃疡 泮托拉唑 半夏泻心汤 一氧化氮 白介素 

分 类 号：R573.1[医药卫生—消化系统]