抑郁症患者识别喜悦面孔时边缘系统信息传递的磁源性影像研究  

Information transmission of the limbic system during positive emotional processing in patients with major depression disorder： a magnetic source imaging study

作　　者：刘晓雪[1] 毕昆 卢青[2] 王强[1] 姚志剑[1] Liu Xiaoxue;Bi Kun;Lu Qing;Wang Qiang;Yao Zhijian.(Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China)

机构地区：[1]南京医科大学附属脑科医院精神科,210029 [2]东南大学生物科学与医学工程学院

出　　处：《中华精神科杂志》2018年第3期169-174,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金（81571639,81371522,61372032）;国家高技术研究发展计划（863计划）（2015AA020509）;江苏省临床医学科技专项（BL2014009）

摘　　要：目的 探究抑郁症患者和健康人在识别喜悦面孔时情绪信息在全脑传递过程中的差异,以及抑郁症患者正性情绪处理加工可能的电生理机制.方法 利用脑磁图分别对34例抑郁症患者（抑郁症组）以及性别、年龄、受教育年限与之相匹配的34名健康对照者（对照组）进行扫描,选取喜悦表情刺激下的脑磁信号,采用一致性方法计算0～600 ms时间段全脑功能连接矩阵,然后计算每个节点的介数中心性值,经非参数检验2组差异有统计学意义的节点与HAMD17总分和各因子分进行Pearson相关分析.结果 在0～600 ms时间段抑郁症组右侧眶部额上回（P=0.000 38,通过FDR校正）、左侧眶内额上回（P=0.000 16,通过FDR校正）、右侧眶内额上回（P=0.000 23,通过FDR校正）、右侧杏仁核（P=0.000 43,通过FDR校正）的介数中心性值均较对照组下降.其中,抑郁症组右侧眶部额上回的介数中心性值与HAMD17总分（r=-0.481,P=0.004）和焦虑/躯体化因子分（r=-0.383,P=0.026）呈负相关,右侧眶内额上回的介数中心性值与HAMD17总分（r=-0.749,P＜0.01）和焦虑/躯体化因子分（r=-0.431,P=0.011）呈负相关.结论 抑郁症患者识别喜悦面孔时边缘系统信息传递异常,尤其是眶额回和杏仁核局部脑区存在信息传递障碍,可能是抑郁症患者正性情绪处理异常的重要病理基础.Objective To investigate whether abnormal betweeness centrality of graph theory analysis during facial emotional processing exists in depression when they recognize happy face with the technology of magnetoencephalography （MEG）,and discuss the possible aberrant mechanism of depression processing.Methods Thirty-four major depressive patients and 34 matched healthy volunteer controls participated in the experiment.The 0-600 ms period MEG signals of 90 brain areas from automatedanatomical labeling template were separated into sequential time intervals.Coherence method was used to identify the functional connectivity matrix.Then betweeness centrality of each node was calculated.The correlation analysis was conducted between the betweeness centrality and the severity of depressive symptoms according to HAMD17 scores.Results Compared with the controls,during 0-600 ms,depressive patients showed decreased betweeness centrality in right super frontal orbital gyrus （P=0.000 38）,left middle orbital frontal gyrus （P=0.000 16）,right middle orbital frontal gyrus（P=0.000 23）,the right amygdala （P=0.000 43）,which were corrected by false discovery rate.Among them,in the depression group,the right superior orbitofrontal cortex betweenness centrality and the total HAMD17 score （r=-0.481,P=0.004） and the anxiety/somatization factor score （r=-0.383,P=0.026） were negatively correlated,and the betweenness centrality of the right middle orbitofrontal gyrus was negatively correlated with the total HAMD17 score （r=-0.749,P〈0.01） and anxiety/somatization factor score （r=-0.431,P=0.011）.Conclusion The limbic system information transmission dysfunction may be the important pathological basis of depression patients with positive emotion processing abnormalities,especially in the orbital frontal gyrus and the amygdaloid nucleus.

关 键 词：抑郁症 脑磁图描记术 杏仁核 情绪面孔 介数中心性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]