儿童血清中微量元素与HCV慢性感染及其清除的关系分析  

The analysis of the relationship between serum trace elements and chronic infection and clearance of HCV in children

作　　者：程倩倩[1] 王娜[1] 焦文志[1] 王芳 CHENG Qian-qian;WANG Na;JIAO Wen-zhi(Kaifeng Center for Disease Control and Prevention, Henan Kaifeng 47500)

机构地区：[1]开封市疾病预防控制中心,河南开封475000 [2]开封市儿童医院,河南开封475000

出　　处：《医学检验与临床》2018年第4期15-17,11,共4页Medical Laboratory Science and Clinics

摘　　要：目的：本研究评估血清微量元素水平与慢性丙型肝炎病毒（HCV）感染及干扰素α（IFN-α）清除疗效的关系.方法：选取2014年10月-2016年9月来开封市儿童医院就诊的35例慢性HCV感染儿童为研究组,同时选取27例健康儿童为对照组.IFN-α治疗之前测定2组患者体内铜（Cu）,锰（Mn）,钼（Mo）,硒（Se）,锌（Zn）的血清水平.IFN-α治疗后,采用生化、 病毒学、 组织病理学3个参数评估IFN-α清除病毒疗效.研究组数据根据IFN-α应答情况分为2组,干扰素应答组（第1组）和干扰素无应答组（第2组）;对照组为第3组.分析治疗后3组患者体内Cu、Mn、Mo、Se、Zn的血清水平.结果：治疗前,研究组Mn、Mo、Se、Zn元素水平显著低于对照组,Cu/Zn比显著高于对照组,差异具有统计学意义（P〈0.01）.治疗后,从生化、 病毒学、 组织病理学3个参数评估均得出：第1组和第2组微量元素水平差异无统计学意义（P〉0.05）;第1组、 第2组Mn、Mo、Se、Zn元素水平均低于第3组,Cu/Zn比均高于第3组,差异具有统计学意义（P〈0.01）.3组Cu元素水平差异无统计学意义（P〉0.05）.结论：慢性HCV感染儿童的Mn,Mo,Se,Zn血清水平显著低于健康对照组,而Cu/Zn比偏高,但对IFN-α治疗的效果没有任何影响.Objective： To evaluate the plasma content of trace elements associated with chronic hepatitis C virus （HCV） infection and interferon-α（IFN-α） clearance in patients. Methods： 35 cases with chronic HCV infection were selected as the study group from October 2014 to September 2016 in Childrens Hospital of Kaifeng. Twenty-seven healthy children were selected as the control group. Serum levels of copper （Cu） , manganese （Mn） , molybdenum （Mo） , selenium （Se） and zinc （Zn） were measured before IFN-α treatment. Using biochemical, virological and histopathology methods to assess the efficacy of IFN-α virus removal. The data were divided into 2 groups according to the response of IFN-α, interferon response group （group 1） and interferon-free response group （group 2） . The control group was setting as group 3. Serum levels ofCu, Mn, Mo, Se and Zn were measured in the three groups after treatment. Results： Before treatment, the Mn, Mo, Se, Zn levels of research group were significantly lower than control group. The study group Cu/Zn ratio was significantly higher （P〈0.01） . After treatment, there was no statistically significant difference in the levels of trace elements between Group 1 and Group 2 （P〉0.05） . The levels ofMr- Mo, Se, and Zn in group 1 and 2 were lower than group 3, but Cu/Zn ratio was higher than group 3 （P〈0.01） . There was no statistical difference in the levels of Cu in the three groups （P〉0.05） . Conclusion： In children with chronic HCV infection, the plasma levels of Mn, Mo, Se and Zn were considerably lower and Cu/Zn ratios were significantly higher compared with healthy controls, and had no effect on the outcome of IFN-α treatment.

关 键 词：儿童 微量元素水平 慢性丙肝感染 干扰素治疗 

分 类 号：R151.4[医药卫生—营养与食品卫生学]