多发性对称性脂肪瘤病临床分析  

Clinical analysis of Madelung's disease

作　　者：刘建敏 曹蜀炜 杨中元[2] LIU Jianmin;CAO Shuwei;YANG Zhongyuan(Department of Otolaryngology Head and Neck Surgery, Deyang Hospital, Chengdu University of TCM, People＇s Hospital of Deyang City, Deyang, Sichuan, 618000, China;Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, China)

机构地区：[1]德阳市人民医院成都中医药大学附属德阳医院耳鼻咽喉头颈外科,四川德阳618000 [2]中山大学肿瘤防治中心头颈外科,广东广州510060

出　　处：《中国耳鼻咽喉头颈外科》2018年第5期229-232,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的总结多发性对称性脂肪瘤病(Madelung病)的临床资料、治疗方法和随访资料,对其发病机制、临床表现及治疗方法进行讨论。方法分析中山大学附属肿瘤医院头颈外科16年间诊治的Madelung病患者的临床资料、颈部的治疗方案和随访资料,对其进行回顾性分析。结果 41例患者中女性1例,男性40例;27例患者有长期酗酒史,14例患者无饮酒史;患者无肥胖体征,颈部为最常见的发病部位;40例患者行外科手术切除,术后外观恢复8例出现皮下脂肪液化、术后出血及切口感染等并发症;随访时间内9例患者复发,所有复发患者均有术前及术后饮酒史。结论 Madelung病为临床少见病,饮酒为独立的危险因素,颈部病变手术为主要治疗手段,分区、分次手术是安全有效的治疗手段,术后需配合戒酒而避免复发。OBJECTIVE Madelung’s disease is a clinically rare disease with unknown pathogenesis.There are no clinical reports of a large sample size for this disease. This paper summarized the clinical data and follow-up information of Madelung’s disease and discussed its pathogenesis, clinical manifestation and therapies.METHODS The clinical data, therapeutic plans for the neck and follow-up information of patients with Madelung’s disease hospitalized at Sun Yat-sen University Cancer Center during 16 years were summarized and subjected to retrospective analysis. RESULTS Only 1 of the 41 patients was female and the others were male. 27 patients had long-term alcohol abuse and 14 patients never drank.None of the patients were obese. The neck was the most frequent site where Madelung took place. There were 40 patients underwent surgical procedure. The appearance of the patients recovered after operation. Eight patients experienced complications such as subcutaneous fat liquefaction, postoperative hemorrhage or wound infection,etc. During the follow-up period, 9 patients recurred after operation because of still drink after operation.CONCLUSION Madelung’s disease is a clinically rare disease. The major therapeutic measure was to remove the neck lesion surgically. The operation should be taken in different steps for different areas. Drinking is an independent risk factor. The patients must stop drinking after operation to avoid recurrence.

关 键 词：脂肪瘤样病 多发性对称性 外科手术 临床特点 

分 类 号：R739.91[医药卫生—肿瘤]