三氧化二砷联合TACE治疗中晚期原发性肝癌疗效的meta分析  

Arsenic trioxide combined with TACE for the treatment of advanced primary hepatic carcinoma:meta-analysis of its curative effect

作　　者：欧东 陈奕霖[1] 付斯瑜[1] 罗德红[1] 屈天银 李曾 OU Dong;CHENG Yilin;FU Siyu;LUO Dehong;QU Tianyia;LI Zeng.(Department of Oncology, Third Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou Province 563000, Chin)

机构地区：[1]遵义医学院第三附属医院肿瘤科,贵州563000

出　　处：《介入放射学杂志》2018年第6期523-529,共7页Journal of Interventional Radiology

摘　　要：目的 评价三氧化二砷(As_2O_3)联合肝动脉栓塞化疗(TACE)治疗中晚期原发性肝癌的疗效。方法 计算机检索万方、中国知网(CNKI)、维普(VIP)、Pubmed、EMbase和SCI数据库中关于As_2O_3联合TACE用于治疗原发性肝癌的文献,检索日期自建库至2017年6月;用Revman5.3软件及Stata12.0对所纳入的研究结果进行meta分析。结果 最终纳入研究18篇,共1 531例患者,其中以As_2O_3联合TACE治疗的(研究组)807例,单纯TACE治疗的(对照组)724例,meta分析结果显示,研究组与对照组的客观有效率(objective response rate,ORR)比较差异有统计学意义(RR=1.42,95%CI=1.20~1.69),生活质量改善率比较差异有统计学意义(RR=1.30,95%CI=1.10~1.53),生活质量降低率比较差异有统计学意义(RR=0.52,95%CI=0.38~0.70),1年生存率比较差异有统计学意义(RR=1.52,95%CI=1.31~1.76),生活质量稳定率比较差异无统计学意义(RR=1.12,95%CI=0.91~1.37)。两组不良反应经对症处理后均可耐受。结论 As_2O_3联合TACE治疗中晚期原发性肝癌有效且安全。Objective To evaluate the curative effect of arsenic trioxide （As2O3） combined with transcatheter arterial ehemoembolization （TACE） in treating advanced primary hepatic carcinoma （PHC）. Methods Computer-based retrieval of literature databases, including Wanfang, CNKI, VIP, PubMed, EMbase and SCI, was conducted to search for articles about As2O3 combined with TACE for the treatment of advanced PHC, and the retrieval time was from the establishment of database to June 2017. Revman5.3 software and Stata12.0 were used to make meta-analysis for the enrolled research resuhs. Results A total of 18 articles containing 1531 patients were included in this study. Among the 1531 patients, As2O3 combined with TACE was employed in 807 patients （study group）, and pure TACE was adopted in 724 patients （control group）. Meta analysis indicated that the differences in following indexes between the study group and the control group were statistically significant： objective response rate （RR =1.42, 95% CI =1.20-1.69）, improvement rate of quality of life （RR=1.30, 95%CI=1.10-1.53）, reduced quality of life （RR=0.52, 95%CI =0.38-0.70）, and one-year survival rate （RR=1.52, 95%CI=1.31-1.76）, while the difference in stabilization rate of quality of life between the two groups was not statistically significant （RR=1.12, 95%CI=0.91-1.37）. In both groups the untoward effects could be tolerated by all patients after symptomatic treatment. Conclusion For the treatment of advanced PHC, As2O3 combined with TACE is safe and effective.

关 键 词：三氧化二砷 介入栓塞 原发性肝癌 META分析 

分 类 号：R735.7[医药卫生—肿瘤]