CT引导下^125I放射性粒子植入治疗浅表恶性肿瘤  

Effect of CT guided implantation of ^125I radioactive particles in superficial malignant tumors

作　　者：付伟[1] 陈士新[1] 李曾[2] 马武[2] 柳仲秋[2] 范志刚[3] 赵志友[1] 田珊 FU Wei;CHEN Shixin;LI Zeng;MA Wu;LIU Zhongqiu;FAN Zhigang;ZHAO Zhiyou;TIAN Shan(l Department of Interventional Radiolog;Department of Oncology;Department of Radiotherapy, the 3201 Hospital Affiliated to Medical School of Xi ＇an Jiaotong University, Hanzhong 723000,China)

机构地区：[1]西安交通大学医学院附属三二0一医院介入科,陕西汉中723000 [2]西安交通大学医学院附属三二0一医院肿瘤内科,陕西汉中723000 [3]西安交通大学医学院附属三二0一医院放疗科,陕西汉中723000

出　　处：《实用放射学杂志》2018年第6期941-943,共3页Journal of Practical Radiology

摘　　要：目的 探讨CT引导下^125I放射性粒子治疗浅表恶性肿瘤的近期疗效。方法 回顾性分析在本院接受CT引导下^125I放射粒子植入治疗的28例恶性浅表肿瘤患者的临床资料。分析患者近期疗效、1年生存率、1年无进展生存率。结果 治疗6个月时患者的客观缓解率（ORR）和疾病控制率（DCR）分别为92.86%和100.00%，1年总生存率和1年无进展生存率分别为96.43%（27/28）、82.14%（23/28）。中位总生存期和中位无进展生存期分别为26.978个月（95%CI：22.558～31.399）、16.932个月（95%CI：14.471～19.393）。0～Ⅱ度不良反应共27例，Ⅲ度不良反应1例，未见Ⅳ度不良反应。未发现^125I放射性粒子移位、血管栓塞以及血管破裂等症状。结论 125I放射性粒子治疗浅表恶性肿瘤近期疗效明确，总生存期和无进展生存期较长且安全性较高，可考虑在临床应用。Objective To investigate the short-term clinical effect of CT guided ^125I radioactive particle therapy in superficial malignant tumor. Methods The clinic data of 28 patients with metastatic superficial malignant tumor in our hospital were analyzed retrospectively.All patients were treated with CT guided ^125I radioactive particle therapy. The short-term effects, 1 year survival rate and 1 year progression free survival rate of the patients were compared.Results Objective remission rate（ORR） and disease control rate（DCR） after 6 months were 92.86% and 100.00%.1 year overall survival and 1 year progression free survival were 96.43 % （ 27/28 ） and 82.14% （ 23/28 ） , respectively.The median overall survival and median progression free survival were 26.978 months （95%CI： 22.558-31.399） and 16.932 months （95%CI： 14.471-19.393）. There were 27 cases of 0～Ⅱ degree adverse reactions,1 case of grade Ⅲ adverse reactions and no grade Ⅳ adverse reactions. No signs of ^125I radioactive particle translocation, vascular embolism and vascular rupture were found. Conclusion ^125I radioactive particle treatment of superficial malignant tumor has a definite short-term curative effect, with overall survival and progression free survival longer and higher safety, which can be considered in clinical application.

关 键 词：浅表恶性肿瘤 ^125I放射性粒子 计算机体层成像 

分 类 号：R739.5[医药卫生—肿瘤] R815[医药卫生—临床医学]