血清脂联素水平与Ⅰ型子宫内膜癌的相关性研究  

Correlation of serum adiponectin level and type Ⅰ endometrial cancer

作　　者：邓露 梁慧瑾 蔡志福[1] 张洁清[1] 李力[1] Deng Lu;Liang Huijin;Cai Zhifu;Zhang Jieqing;Li Li(Department of Gynecologic Oncology,Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021,China;Department of Obstetrics,Affiliated Hospital of Jining Medical University, Jining 272029, China)

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,南宁530021 [2]广西医科大学研究生院 [3]济宁医学院附属医院产科,济宁272029

出　　处：《中国癌症防治杂志》2018年第3期225-228,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

基　　金：国家自然科学基金资助项目(81160318);广西自然科学基金资助项目(2015GXNSFAA139127);广西区域性高发肿瘤早期防治研究教育部重点实验室资助项目(GK2015-ZZ08);广西医疗卫生自筹课题(Z2015627)

摘　　要：目的探讨血清脂联素水平与Ⅰ型子宫内膜癌的关系。方法回顾性分析我院收治的34例新发Ⅰ型子宫内膜癌患者和24例正常子宫内膜患者的临床资料,检测空腹血清葡萄糖、空腹血胰岛素、血清脂联素水平,采用logistic回归分析血清脂联素水平与子宫内膜癌发生的关系。结果Ⅰ型子宫内膜癌患者血清脂联素水平与肿瘤FIGO分期、组织学分化程度、肌层浸润深度、宫颈受累、淋巴结转移情况无关(P>0.05)。单因素logistic回归分析结果显示,以脂联素高水平组为对照,脂联素低水平组罹患子宫内膜癌的风险高于高水平组(OR=8.125,95%CI:1.874~35.233,P=0.005);中水平组罹患子宫内膜癌的风险高于高水平组(OR=4.024,95%CI:1.060~15.278,P=0.041)。调整空腹胰岛素水平或HOMA-IR指数等可能混杂因素后,这种关系依然存在。结论血清脂联素水平越低,罹患子宫内膜癌的风险越高,低血清脂联素水平可能促进子宫内膜癌发生发展。Objective To investigate the relationship between serum adiponectin and type I endometrial cancer. Methods Medical records were retrospectively reviewed for 34 patients with newly diagnosed endometrial cancer and 24 women with normal endometrium at the Affilated Tumor Hospital of Guangxi Medical University. The two groups were compared in terms of serum adiponeetin,fasting serum insulin （FINS）,and fasting blood glucose （FBG）. Logistic regression was used to explore relationships between serum adiponectin levels and type [ endometrial cancer. Results Serum adiponectin levels in patients were independent of clinico-pathological features such as surgical stage,pathology grade, myometfial invasion, cervical involvement, and lymph node metastasis （P〉0.05）. The control group showed a high adiponectin level. Univariate logistic regression showed that relative to individuals with high adiponectin levels, those with low adiponectin levels were at significantly higher risk of endometrial cancer （OR=8.125,95%CI： 1.874-35.233,P=0.005 ）, as were those with intermediate adiponectin levels （OR=4.024,95%CI： 1.060-15.278 ,P=0.041 ）. Similar results were obtained after adjusting for fasting insulin levels or HOMA-IR index. Conclusion Risk of endometrial cancer seems to vary inversely with serum adiponectin level. Low serum adiponectin levels may promote the development of endometrial cancer.

关 键 词：子宫肿瘤 血清脂联素 相关性研究 LOGISTIC回归 风险 

分 类 号：R737.33[医药卫生—肿瘤]