中西医结合治疗反流性食管炎疗效研究  

Curative Effect of Integrated Traditional Chinese and Western Medicine on Reflux Esophagitis

作　　者：孙丽伟[1] 吴建良[1] 金娟[1] 黄丽萍 王志勇[1] SUN Liwei;WU Jianliang;JIN Juan;HUANG Liping;WANG Zhiyong(Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China)

机构地区：[1]杭州师范大学附属医院消化内科

出　　处：《中华中医药学刊》2018年第6期1511-1514,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生科技计划项目(2015KYB299)

摘　　要：目的：探讨疏肝温胃方联合西医治疗反流性食管炎患者的疗效。方法：选取2016年1月-2017年1月在本院门诊治疗的反流性食管炎患者102例，根据数字表法将患者分为西医治疗组和中西医联合治疗组，每组51例，西医治疗组患者给予口服奥美拉唑肠溶胶囊和枸橼酸莫沙必利分散片，中西医联合治疗组患者在西医治疗组的基础上给予疏肝温胃汤，治疗周期4周，比较比较两组患者的总体临床疗效，胃镜观察疗效，食管炎的临床症状评分，食管压力，返流次数，不良反应，随访6个月，统计复发情况。结果：中西医联合治疗组临床总有效率高于西医治疗组，差异具有统计学意义；中西医联合治疗组胃镜疗效的有总效率高于西医治疗组，差异具有统计学意义；中西医联合治疗组患者反酸、烧心以及胸骨后灼痛的评分均低于西医治疗组，差异具有统计学意义；中西医联合治疗组下括约肌松弛率高于西医治疗组，中西医联合治疗组食管体异常收缩比例低于西医治疗组，差异具有统计学意义；中西医联合治疗组总反流次数少于西医治疗组，差异具有统计学意义；两组患者的不良反应的发生率的差异无统计学意义；西医治疗组6个月复发率为31．4％，中西医联合治疗组6个月复发率为9．8％（X^2=7．185，P=0．007），两组的差异具有统计学意义。结论：将疏肝温胃方剂联合西医治疗反流性食管炎患者的治疗可以显著提升疗效，有效改善临床症状，改善括约肌功能和食管收缩功能，降低反流频率，值得临床推广。Objective： To investigate the curative effect of Prescription of Soothing Liver and Warming Stomach com- bined with Western medicine in treatment of patients with reflux esophagitis. Methods ： A total of 102 patients with reflux esophagitis who were treated in our hospital from January 2016 to January 2017 were selected and divided into Western medicine treatment group and traditional Chinese medicine combined with Western medicine treatment group according to the number table method, 51 cases in each group. Western medicine treatment group were given oral Omeprazole Enteric -coated Capsules and Mosapride Citrate Dispersible Tablets. The traditional Chinese medicine combined with Western medicine treatment group on the basis were given Prescription of Soothing Liver and Warming Stomach. The treatment cy- cle was 4 weeks, and the overall clinical efficacy, the curative effect, the clinical symptom score, the esophageal pres- sure, the number of reflux and the adverse reactions were was compared. The patients were followed up for 6 months, and the recurrence was statistically analyzed. Results： The total effective rate of the traditional Chinese medicine combined with Western medicine treatment group was higher than that of Western medicine treatment group, and the difference was statistically significant. The total effective rate of gastroscopy in Chinese medicine combined with Western medicine treat- mentgroup was higher than that in the Western medicine treatment group, and the difference was statistically significant. Patients with acid reflux, heartburn, chest pain scores in Chinese medicine combined with Western medicine treatment- group were less than the Western medicine treatment group＇ s, and the difference was statistically significant. The relaxa- tion rate of lower sphincter of Chinese medicine combined with Western medicine treatmentgroup was higher than that of Western medicine treatment group, and the proportion of abnormal contraction of esophageal body was also lower than that in Western m

关 键 词：疏肝温胃方 西医治疗 中西医结合 反流性食管炎 

分 类 号：R571[医药卫生—消化系统]