放疗联合植入式导管药盒系统同期化疗治疗局部晚期宫颈癌的效果分析  

Concurrent radiotherapy combined with chemotherapy using implanted port catheter systems for local advanced cervical cancer

作　　者：黄荣[1] 何耀强[2] 曾晓红[1] 周菲菲[1] HUANG Rong;HE Yao-qiang;ZENG Xiao-hong;ZHOU Fei-fei(Department of Radiotherapy, First People＇s Hospital of Foshan, Foshan 528000, Chin)

机构地区：[1]广东省佛山市第一人民医院放疗科,佛山528000 [2]广东省佛山市第一人民医院放射科,佛山528000

出　　处：《中国肿瘤临床与康复》2018年第5期546-549,共4页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：国家重点研发计划数字诊断装备研发重点专项课题经费资助(2017YFC0113200)

摘　　要：目的探讨放疗联合植入导管药盒系统(PCS)同期化疗治疗局部晚期(ⅡB~ⅢB期)宫颈癌的疗效和不良反应。方法选取2012年5月至2015年5月间广东省佛山市第一人民医院收治的111例ⅡB~ⅢB期宫颈癌患者,其中放疗联合同期PCS化疗54例患者纳入治疗组,常规同期放化疗57例患者纳入对照组。治疗组患者采用Seldinger法行右侧股动脉穿刺,一侧子宫动脉行栓塞术,将PCS导管导入后留置在髂内动脉用于化疗至放疗结束。结果中位随访时间为56个月。治疗组患者近期有效率为92.6%,对照组为77.2%;治疗组患者肿瘤中位无进展生存时间为59个月,对照组为53个月;治疗组患者局部复发率为11.1%,对照组为26.3%;治疗组患者Ⅲ度以上消化道和血液学不良反应均低于对照组,两组比较,差异均有统计学意义(均P<0.05)。两组患者远处转移率、3年生存率和远期并发症比较,差异无统计学意义(P>0.05)。结论放疗联合同期PCS化疗治疗局部晚期宫颈癌近期疗效好,肿瘤局部控制率高,不良反应较轻,有一定的临床推广价值,远期疗效有待进一步观察。Objective To explore the efficacy and adverse effect of radiotherapy combined with chemotherapy using the implanted port catheter systems（PCS）for locally advanced（stageⅡB~ⅢB）cervical cancer.Methods A total of 111 patients with stage IIB^IIIB cervical cancer treated at First People＇s Hospital of Foshan were retrospectively analyzed from May 2012 to May 2015.Among them,54 patients had radiotherapy combined with weekly chemotherapy using PCS（study group）and 57 patients concurrently had conventional chemoradiotherapy（control group）.For patients in study group,puncturing of right femoral artery was performed using Seldinger＇s technique,which was followed by embolization in one side of the uterine artery.The catheter used for PCS was imported into the contra-lateral internal iliac artery,and left inside until the completion of the radiation therapy session.ResultsMedian follow-up time was 56months.The short-term efficacy rate was 92.6%and 77.2%for the study group and the control group respectively.The median progression-free survival was 59 months and 53 months for the study group and the control group respectively.The local recurrence rate was 11.1%and 26.3%respectively for the study group and the control group.The digestive tract and hematologic adverse effects above grade III was significantly lower in the study group than in the control（all P0.05）.There was no significant difference in the rate of distant metastasis and 3-year survival rates,as well as long-term complications between the two groups.ConclusionRadiotherapy combined with chemotherapy using PCS for locally advanced cervical cancer shows high short-term treatment efficacy and local control rate with few adverse effects,which has certain clinical significance.The long-term efficacy needs further observation.

关 键 词：子宫颈肿瘤 动脉灌注化疗 同期放化疗 植入式导管药盒系统 

分 类 号：R737.3[医药卫生—肿瘤]