郁消散外敷对癌痛患者β内啡肽和P物质的影响  

Effect of external application of yuxiaosan on β-endorphin and substance P in patients with cancer pain

作　　者：王淑美 王维[2] 李配富[2] 刘朝菊 胡云 熊本立 WANG Shu-mei;WANG Wei;LI Pei-fu;LIU Chao-ju;HU Yun;XIONG Ben-li(Teaching and Research Section of Clinical Research of Traditional Chinese Medicine, College of Traditional Chinese Medicine,Chongqing Medical University, Chongqing 400016, China;Department of On- cology Treated with Traditional Chinese Medicine, Chongqing cancer Hospital, Chongqing 400030, China;Department of Internal Medicine, Chongqing Yubei Traditional Chinese Medicine Hospital, Chongqing 401120,China;Department of Oncology, Chongqing Tongliang Traditional Chinese Medicine Hospital, Chongqing 402560, China)

机构地区：[1]重庆医科大学中医药学院中医临床教研室,重庆400016 [2]重庆市肿瘤医院中医肿瘤科,重庆400030 [3]重庆市渝北区中医院内科,重庆401120 [4]重庆铜梁中医院肿瘤科,重庆402560

出　　处：《中国肿瘤临床与康复》2018年第5期560-562,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：重庆市卫生局课题(渝中医[2012]41)

摘　　要：目的探讨郁消散外敷对癌痛患者止痛的作用机制。方法选取2012年8月至2015年8月间重庆市肿瘤医院、重庆市渝北区中医院和重庆铜梁中医院收治的80例癌痛患者,采用随机数表法分为试验组和对照组,每组40例。对照组患者采用三阶梯止痛方法,试验组患者采用郁消散外敷加三阶梯止痛方法,1次/d,6h/次,两组均治疗7d。采用数字评分法(NRS)对敷药前后疼痛缓解度进行比较。采用ELISA法检测两组患者治疗前后血清β内啡肽(β-EP)和P物质的含量变化。结果试验组患者癌痛缓解率优于对照组(P<0.01)。两组患者治疗后β-EP表达较治疗前显著升高,P物质表达较治疗前显著降低,两组比较,差异均有统计学意义(均P<0.01)。结论郁消散外敷能有效减轻癌痛,升高患者血清β-EP和降低血清P物质含量,可能是其止痛机制之一。Objective To investigate the possible mechanism of external application of yuxiaosan in releasing cancer pain. Methods From August 2012 to August 2015,80 patients with cancer pain were selected at Chongqing cancer Hospital, Chongqing Yubei Traditional Chinese Medicine Hospital and Chongqing Tongliang Traditional Chinese Medicine Hospital. These patients were divided randomly into an experiment group and a control group. The experimental group was treated with external application of yuxiaosan combined with three-step analgesic therapy and the control group was only treated with three-step analgesic therapy once daily with 6 h for 7 d. Degree of pain relief was compared by score of numerical rating scale（NRS）. The changes in serum β-endorphin（β-EP） and substance P were measured with ELISA before and after the treatment. Results The relief rate was significantly better in the experiment group than in the control group（P〈0. 01）. The expression of β-EP was significantly increased and the expression of substance P was significantly decreased（all P〈0. 01）. Conclusion External application of yuxiaosan can effectively relieve the cancer pain elevating serum β-EP level and reducing serum substance P level in patients with cancer pain,which may be one of its potential mechanism.

关 键 词：郁消散 癌痛 血清β内啡肽(β-EP) P物质 

分 类 号：R730.6[医药卫生—肿瘤]