胃肠道间质瘤耐药机制研究方法的应用进展  

Progress in the study of the mechanism of drug resistance in gastrointestinal stromal tumors

作　　者：潘力迦 董平[1] Pan Lijia;Dong Ping(Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shang- hai 200092, Chin)

机构地区：[1]上海交通大学医学院附属新华医院普外科,200092

出　　处：《中华实验外科杂志》2018年第6期1180-1183,共4页Chinese Journal of Experimental Surgery

摘　　要：胃肠道间质瘤（GISTs）是最常见的消化道恶性肿瘤之一，且对放化疗皆不敏感。酪氨酸激酶抑制剂（TKIs）作为特效药应用于临床治疗后取得了显著疗效，但随之而来的耐药性限制了其临床应用。随着相关机制研究不断深入，新颖的治疗药物也层出不穷。可见，关于胃肠道问质发病机制的基础研究对于发现治疗新方法至关重要。目前至少有3种模型被广泛应用于肿瘤发病机制的基础研究实验，即同源耐药／敏感细胞株模型，肿瘤移植小鼠模型，还有人体肿瘤标本。本文将回顾有天胃肠道间质瘤耐药机制研究方法的文献，对相关研究方法和发现的主要耐药机制进行系统综述。gastrointestinal stromal tumors （GISTs） are one of the most common malignant tumors of digestive tract, and are resistant to cytotoxic radiotherapy and chemotherapy. Tyrosine kinase inhibitors （TKls） have been used as a miracle drug for clinical treatment. However, the drug resistance has limited its clinical application. With the con- tinuous deepening understanding of the relevant mechanisms, novel therapeutic agents are emerging. Therefore, funda- mental studies on the pathogenesis of gastrointestinal stromal tumor are essential for the discovery of novel therapeutic approaches. At present, there are at least three models which are widely applied in the basic research of the pathogeue- sis of tumor, which are the homologous resistant/sensitive cell line model, the tumor transplanted mouse model, and the human tumor specimen. In this paper, we review the literature on the research methods of gastrointestinal stromal tumor resistance mechanism, and summarize the related research methods and the main mechanisms of drug resistance.

关 键 词：肿瘤细胞株 胃肠道间质肿瘤 耐药 肿瘤移植 人体肿瘤标本 

分 类 号：R735[医药卫生—肿瘤]