老年结直肠癌的临床病理特征和预后  

Clinicopathological characteristics and prognosis of elder colorectal cancer patients

作　　者：杨姣 傅健飞[2] 谭伊诺[3] 蒋梦婕 文飞 袁瑛[3] Yang Jiao;Fu Jianfei;Tan Yinuo;Jiang Mengjie;Wen Fei;Yuan Ying(Department of Medical Ontology, the First Affiliated Hospitalof Xi＇an Jiaotong University, Xi＇an 710061, China;Department of Medical Oncology,Jinhua Central Hospital, Jinhua 321001, China;Department of Medical Oneology, the Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 310009, China;Department of Radiotherapy,Zhejiang Provincial Hospital of TCM, Hangzhou 310002, China;Cancer Institute,the Second Affiliated Hospital,Zhejiang University,School of Medieine, Hangzhou 310009, China)

机构地区：[1]西安交通大学附属第一医院肿瘤内科,陕西西安710061 [2]金华市中心医院肿瘤内科,浙江金华321001 [3]浙江大学医学院附属第二医院肿瘤内科,浙江杭州310009 [4]浙江省中医院放疗科,浙江杭州310002 [5]浙江大学医学院附属第二医院肿瘤研究所,浙江杭州310009

出　　处：《实用肿瘤杂志》2018年第3期228-233,共6页Journal of Practical Oncology

摘　　要：目的分析老年结直肠癌的临床病理特征和预后。方法回顾性分析经术后病理确诊为结直肠腺癌的2 460例患者的临床资料。比较老年组(≥70岁)和年轻组(<70岁)的临床病理特征和术后生存情况。结果2 460例患者中位年龄59岁,老年组544例(22.1%),年轻组1 916例(77.9%)。老年结直肠癌患者以男性、结肠部位和管状腺癌多见(均P<0.05),远处转移较少(P=0.008),但接受姑息术治疗的比例高(P=0.005)。老年组和年轻组的术后10年总生存比较,差异无统计学意义(P=0.601)。Ⅱ期疾病患者中,老年组术后5年总生存率较年轻组差(P=0.008)。结论老年结直肠癌患者的术后总生存不差于年轻患者。Ⅱ期患者中,老年患者预后较差。Objective To analyze the clinicopathological characteristics and prognosis of elder patients with colorectal cancer. Methods The clinical data of 2 460 cases of pathologically diagnosed colorectal cancer patients were studied retrospectively. The clinical characteristics and postoperative survival rates were compared between the elder group（ ≥70 years old） and young group（〈 70 years old）. Results Among all patients,the median age was 59 years old,with 544（ 22. 1%） patients categorized in the elder group and 1 916（ 77. 9%） cases categorized in the young group. In the elder group,there were more cases of male patients,colon tumors and tubular adenocarcinoma（ all P〈0. 05）,fewer cases of long distance metastasis（ P = 0. 008）,and more cases of palliative surgery（ P = 0. 005）. However,no significant difference was found on the 10-year overall survival rates between the elder and the young groups（ P = 0. 601）. Nevertheless,among stage Ⅱ patients,the 5-year overall survival rate was lower in the elder group than that in the young group（ P =0. 008）. Conclusion The overall postoperative survival rates were comparable between the elder and the young colorectal cancer patients,but stage Ⅱ elder patients had poor prognosis.

关 键 词：结直肠肿瘤 外科学 预后 回顾性研究 

分 类 号：R735.3[医药卫生—肿瘤]