吸烟、饮酒和膳食因素对高尿酸血症人群中高血压的影响  

Effects of smoking,drinking and dietary factors on hypertension in subjects with hyperuricemia

作　　者：邢慧媛 刘琰 赵艾[2] 郑薇 李婷 郑迎东[6] 王颜 张玉梅[1] XING Hui-yuan;LIU Yan;ZHAO Ai;ZHENG Wei;LI Ting;ZHENG Ying-dong;WANG Yan;ZHANG Yu-mei(Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China;Department of Social Medicine and Health Education, School of Public Health, Peking University, Bering 100191, China;Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;Yili Innovation Center, Inner Mongolia Yili Industrial Group Co. , Ltd. , Hohhot 010110, China;Innovation Center, Inner Mongolia Dairy Technology Research Institute Co. , Ltd. , Hohhot 010110, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking. University, Beijing 100191, China)

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,北京100191 [2]北京大学公共卫生学院社会医学与健康教育系,北京100191 [3]首都医科大学附属北京妇产医院围产内分泌代谢科,北京100026 [4]内蒙古伊利实业集团股份有限公司创新中心,内蒙古呼和浩特010110 [5]内蒙古乳业技术研究院有限责任公司创新中心,内蒙古呼和浩特010110 [6]北京大学公共卫生学院流行病学与卫生统计学系,北京100191

出　　处：《中华疾病控制杂志》2018年第6期555-559,共5页Chinese Journal of Disease Control & Prevention

摘　　要：目的探讨我国成人高尿酸血症(hyperuricemia,HUA)人群中高血压与吸烟、饮酒和膳食因素的相关性,为综合防治HUA和高血压提供依据。方法 2016年,对中国8城市成年人群通过问卷调查、身体测量和实验室检测等手段展开膳食与健康关系调查,并将334例患HUA的研究对象按是否有高血压分为高血压组(169例)和对照组(165例),采用多因素Logistic回归分析探讨相关影响因素。结果高血压组女性血尿酸水平高于对照组(t=3.374,P=0.001),且超重或肥胖者占76.3%,对照组占53.3%(x^2=21.512,P<0.001);饮食营养方面,高血压组脂肪供能比低于对照组(t=-2.416,P=0.016),但碳水化合物的供能比高于对照组(t=2.651,P=0.008)。多因素Logistic回归分析结果显示,HUA者中,超重、肥胖和适量摄入蔬菜是患高血压的危险因素,喝咖啡和禽畜肉摄入过多是患高血压的保护因素;调整年龄、性别后,仅超重(OR=2.06,95%CI:1.14~3.71)和肥胖(OR=4.55,95%CI:2.11~9.81)是HUA者患高血压的危险因素。结论对于HUA人群,在控制血尿酸水平的基础上,为避免高血压的发生,应注意合理膳食,控制身体质量指数保持适宜体重。Objective To investigate the relationship between hypertension in subjects with hyperuricemia （HUA） and smoking, drinking and dietary factors in China＇ s adults, and provide evidence for the prevention and treatment of hy- peruricemia and hypertension. Methods In 2016, questionnaires, body measurements and laboratory tests were conduc- ted to investigate the relationship between diet and health status for adults from 8 Chinese cities. 334 subjects with hyperu- ricemia were divided into two groups based on their hypertension status： hypertension group （ 169 cases with hypertension） and control group （165 cases without hypertension）. Multivariate Logistic regression analysis was conducted to explore the relevant factors. Results Serum uric acid level for female subjects in hypertension group was significantly higher than that in control group （t = 3. 374, P = 0. 001 ）. Overweight or obesity accounted for 76. 3% in hypertension group, and 53.3% in control group （ X2 = 21. 512, P 〈 0. 001 ）. For dietary nutrition, the energy from dietary fat in control group was higher than that in hypertension group （t = -2. 416, P =0. 016）, while the energy from dietary carbohydrate was opposite （t = 2. 651, P = 0. 008 ）. Multivariate logistic regression analysis showed that overweight, obesity, and appropriate vegetable in- take were risk factors, while coffee drink and excessive meat intake were protective factors for hypertension in subjects with hyperuricemia. After adjusted for age and sex, multivariate Logistic regression indicated that only overweight （ OR = 2. 06, 95% CI： 1.14-3.71 ） and obesity （ OR = 4. 55, 95 % CI： 2. 11-9. 81 ） were risk factors. Conclusions People should con- trol their high SUA level first if they have already had HUA. In order to avoid hypertension, one should also pay attention to eat healthily to maintain weight and body mass index in good level.

关 键 词：高尿酸血症 高血压 膳食 吸烟 饮酒 

分 类 号：R544.1[医药卫生—心血管疾病] R151[医药卫生—内科学]