血清bFGF浓度与老年人药物过度使用性头痛程度及疗效的关系  

Relations of serum level of b FGF with elderly medication overuse headache and curative effect

作　　者：叶建新 张冬梅 林丽虹 陈建鸿 余云华 崔晓萍 YE Jian-xin;ZHANG Dong-mei;LIN Li-hong(Department of Neurology, Fuzhou General Hospital of Fujian Medical University （Fuzhou General Hospital）, Fuzhou , Fujian 350025, Chin)

机构地区：[1]福建医科大学福总临床医学院(福州总医院)神经内科,福建福州350025 [2]福建医科大学福总临床医学院(福州总医院)干部二科

出　　处：《中华全科医学》2018年第8期1254-1256,1363,共4页Chinese Journal of General Practice

基　　金：全军保健专项课题(14BJZ30)

摘　　要：目的研究和探讨血清碱性成纤维细胞生长因子(b FGF)浓度与老年人群药物过度使用性头痛(MOH)的相关性。方法选取2014年7月—2015年7月于福州总医院门诊或住院治疗的60例确诊为MOH的老年患者纳入研究组,另选取同期于该院治疗的60例非药物过度使用头痛的老年患者为对照组,对比2组患者疼痛视觉模拟(VAS)评分及血清b FGF浓度,并将MOH组内患者根据头痛程度进行分级,统计患者所服用的止痛药物,分析不同级别患者的b FGF浓度与疼痛程度、服用药物的相关性,然后对MOH组患者进行撤药及预防性治疗,分别于治疗后1、2、3个月对比患者VAS评分及血清b FGF浓度。结果 (1)MOH组患者的VAS评分及血清b FGF浓度高于非MOH组,差异具有统计学意义(P<0.01);(2)MOH组内,血清b FGF浓度和头痛级别及VAS评分均呈正相关(r=0.756,P<0.01;r=0.698,P<0.01),服用不同种类药物的患者VAS评分差异无统计学意义,b FGF水平差异无统计学意义(P>0.05);(3)治疗后1、2、3个月后患者头痛程度缓解,VAS评分降低,相应的血清b FGF浓度降低,差异有统计学意义(P<0.01)。结论血清b FGF可以作为诊断MOH的参考指标,且在老年患者中,b FGF浓度与MOH头痛程度呈正相关,与所服用药物无关,可以作为疗效评价指标。Objective To investigate the relationship between serum levels of basic fibroblast growth factor （bFGF） and medication overuse headache （MOH） in the elderly patients. Methods Sixty elderly patients diagnosed with MOH were enrolled in the study group from July, 2014 to July, 2015, and 60 elderly patients who were treated with non-drug over- dose were selected from our hospital The patients were divided into two groups according to the VAS score and the serum bFGF concentration. The patients in the MOH group were graded according to the degree of headache. The analgesic drugs taken by the patients were analyzed. The levels of bFGF and the degree of pain were analyzed. The patients were followed by withdrawal and prophylaxis in the MOH group. The VAS score and serum bFGF concentration were compared between 1 month, 2 months and 3 months after treatment. Results （1） The VAS score and serum bFGF concentration in the MOH group were significantly higher than those in the non-MOH group （P 〈 0.01 ） ; （2）There was a positive correlation between the serum bFGF concentration and the headache grade and VAS score （P 〉 0. 05）. （3） One month and two months after treatment, there were no significant differences in VAS scores between the two groups （ P 〉0. 05 ） , and the difference was not significant （ P 〉 0.05 ） After 3 months, the patient＇ s headache was relieved, the VAS score decreased, and the corresponding serum bFGF concentration decreased, the difference was statistically significant （ P 〈 0.01 ）. Conclusion Serum bFGF can be used as a reference index for diagnosis of MOH. In elderly patients, bFGF concentration is positively correlated with MOH headache level, and it can be used as an evaluation index.

关 键 词：血清碱性成纤维细胞生长因子 药物过度使用性头痛 老年患者 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R969.3[医药卫生—临床医学]