格尔木地区居民胃食管反流病流行病学调查分析  

Epidemiologic investigation and analysis of gastroesophageal reflux disease in the population of Golmud in Qinghai Province

作　　者：姚小军[1] 王晨[1] 程传斌 张鹏 陈亮亮 衣云强 施怡 YAO Xiao-jun;WANG Chen;CHENG Chuan-bin(Department of Gastroenterology, the Twenty-second Hospital of PLA, Golmud, Qinghai 816099, China)

机构地区：[1]解放军第22医院消化内科,青海格尔木816099

出　　处：《中华全科医学》2018年第8期1386-1388,共3页Chinese Journal of General Practice

摘　　要：目的探讨格尔木地区居民中患胃食管反流病(GERD)的情况。方法自2014年6月—2015年5月,采取多级分层随机整群抽样方法,使用中文版反流性疾病问卷(RDQ),采用面访式方式进行调查,在格尔木地区内随机选取城区、城乡结合区、农牧区作为调查区域。对抽样区域中年龄在18岁以上,且在格尔木地区连续生活3年以上居民进行问卷调查。所有资料均录入excel软件并建立数据库,用SPSS 16.0统计软件对数据进行分析。结果收回有效问卷3 015份,应答率为91.36%,按RDQ值(≥12分)定义,格尔木地区的标准化患病率为9.41%(284/3 015),男性高于女性分别为9.51%和9.03%,男女患病率组间差异无统计学意义(P>0.05);18~44岁年轻人群、45~59岁中年人群、60~74岁年轻老年人群及75岁以上老年人群GERD的患病率分别为8.04%、11.59%、10.34%及8.14%,各年龄段患病率组间差异无统计学意义(P>0.05);汉族、蒙古族、回族、藏族的患病率分别为9.51%、9.09%、11.07%、6.52%,各少数民族与汉族间患病率差异无统计学意义(P>0.05);GERD的患病率与BMI指数呈正相关,当BMI≥35 kg/m2时,胃食管反流病(GERD)患病率明显升高;Logistic多元回归分析显示进食过饱、高脂肪饮食、辛辣食物、大量饮高度白酒、进食后2 h内就寝、精神紧张及便秘均为罹患GERD的高危因素(P<0.05),高盐饮食、甜食、浓茶、咖啡与GERD的发生无明显相关性(P>0.05)。结论格尔木地区居民中GERD患病率明显高于北京、上海两地;进食过饱、高脂肪饮食、甜食、辛辣食物、大量饮高度白酒、进食后2 h内就寝、精神紧张、便秘及肥胖可能与高原地区GERD发病率高有关。Objective To investigate the prevalence of gastroesophageal reflux disease （GERD） in the population of Golmud in Qinghai Province. Methods From June, 2014 to May, 2015, a random sampled investigation was applied by using Reflux Disease Questionnaire （RDQ） in Golmud area. A face-to-face interview was applied to residents over 18 and living here more than 3 years in the urban area, urban fringe area and agricultural and pastoral area. All data were entered in excel and the SPSS 16.0 software was carried out to perform the data analysis. Results A total of 3 015 valid questionnaires were retrieved and the response rate was 91.36%. The prevalence of CERD in Golmud area was 9.41% （ 284/3 015 ） according to the definition （ RDQ score 1〉 12）. The prevalence of GERD in male was higher than in female with 9.51% vs. 9.03%, respectively, and no significant difference was found between the two groups （P 〉0.05）. The prevalence of GERD among people aged 18 - 44 years old, 45 - 59 years old, 60 - 74 years old and aged over 75 were 8.04% , 11.59% , 10.34% and 8.14% respectively, without statistical difference among groups （ P 〉 0.05 ）. The prevalence rates of Han, Hui, Tibetan arid Mongolian were 9.51% , 11.07% , 6.52% and 9.09% , respectively. There was no significant difference between minorities and Han（ P 〉 0.05 ）. The prevalence of GERD was positively correlated with BMI, especially when BMI≥ 35, the GERD prevalence was significantly increased. Logistic regression analysis showed that high risk of GERD was caused by satiety, high-fat diet, spicy food, high alcohol consumption, sleeping with- in 2 hours after eating, psychentonia and constipation （ P 〈 0.05 ）, while high-salt diet, sugar confectionery, strong tea and coffee had no significant correlation with GERD （P 〉 0.05）. Conclusion The prevalence of GERD in the population of Golmud area was significantly higher than that in Beijing and Shanghai. Satiety, high-fat diet, sugar confectionery, spicy food, high alcohol consum

关 键 词：胃食管反流病 流行病学调查 格尔木地区 高原 

分 类 号：R571[医药卫生—消化系统] R573[医药卫生—内科学]