刺激响应型纳米载体在肿瘤诊疗中的研究进展  

Research Progress of Stimuli Responsive Nanocarriers in Diagnosis and Treatment of Cancer

作　　者：田浩 赵鹏飞[2] 郑明彬 马爱青[1,2] 罗震宇 陈世春[1] 鲁澄宇 蔡林涛 TIAN Hao;ZHAO Peng-Fei;ZHENG Ming-Bin;MA Ai-Qing;LUO Zhen-Yu;CHEN Shi-Chun;LU Cheng-Yu;CAI Lin-Tao(Key Laboratory for Nanomedieine of Guangdong Medical University, Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Medical University, Dongguan 523808, China;CA S Key of Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedieine, Shenzhen Institutes of A dvaneed Technology, Chinese Academy of Sciences, Shenzhen 518055, China)

机构地区：[1]广东医科大学东莞市药物设计与制剂技术重点实验室广东医科大学纳米药物制剂重点实验室,东莞523808 [2]中国科学院深圳先进技术研究院中国科学院健康信息学重点实验室广东省纳米医药重点实验室深圳癌症纳米技术重点实验室,深圳518055

出　　处：《生物化学与生物物理进展》2018年第6期593-600,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(21375141;81401509;81371679;21404115;81401520;21701033);重要国际科技合作项目(2015DFH50230);广东省自然科学基金(2017A030313079;2017A030313726);东莞社会科技发展项目(2015108101019);中国博士后基金面上项目(2017M612803);广东医科大学科研基金面上培育项目(M2016006)资助~~

摘　　要：刺激响应型纳米载体是通过对外界刺激响应而产生相应结构或理化性质变化的纳米智能载药体系,具有避免药物过早泄露,提高病灶药物浓度的特点,目前已成为肿瘤诊断和治疗领域的研究热点,广泛用于控制药物的呈递和释放.本文从温度、磁场、超声、光、pH等外源和内源刺激角度,阐述了智能响应型纳米载体近年来在肿瘤诊疗领域的研究进展.Stimuli responsive nanocarriers as nano-intelligent drug delivery system could make corresponding change in structure and physicochemical properties for response to external stimulus.Take the advantages of avoiding premature drug release and improving the drug concentration in the lesion, they have become a focus in diagnosis and treatment of cancer and were widely used to control drug delivery and release.Based on the temperature, magnetic field, ultrasonic, light, p H and other endogenous and endogenous stimulus, we reviewed the recent research development of stimuli responsive nanocarriers in the field of tumor diagnosis and treatment in this paper.

关 键 词：刺激响应 药物释放 纳米载体 药物传递 肿瘤 

分 类 号：R73[医药卫生—肿瘤]