apoA-Ⅰ的α螺旋在胆固醇流出中的作用  

The Role of apoA-Ⅰ's α-Helix in Cholesterol Efflux

作　　者：高嘉慧 莫中成[2] 唐朝克[1] GAO Jia-Hui;MO Zhong-Cheng;TANG Chao-Ke(） Institute of Cardiovascular Disease, Key Lab for Arterioselerology of Hunoar Province, Hengyang 421001, China;） Clinical Natomy ＆ Reproductive Medicine Application Institute, Department of Histolong and Embryology, University of South China, Hengyang 421001, China)

机构地区：[1]南华大学心血管疾病研究所动脉粥样硬化学湖南省重点实验室医学研究实验中心,衡阳421001 [2]南华大学医学院应用解剖与生殖医学研究所组织学与胚胎学教研室,衡阳421001

出　　处：《生物化学与生物物理进展》2018年第6期629-636,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(81770461)~~

摘　　要：血浆载脂蛋白A-Ⅰ(apoA-Ⅰ)的水平与动脉粥样硬化(atherosclerosis,AS)性心血管疾病的风险呈负相关.ApoA-Ⅰ经载脂形成高密度脂蛋白(HDL),HDL通过促进胆固醇逆向转运(RCT),使细胞内的多余胆固醇流出.α螺旋是apoA-Ⅰ载脂的主要结构,在apoA-Ⅰ参与的胆固醇流出中具有重要作用.模拟α螺旋建立的apoA-Ⅰ模拟肽能通过不同方式发挥抗AS的作用.本文就α螺旋在胆固醇流出中的作用作一综述,以便进一步探索apoA-Ⅰ的结构对胆固醇流出的影响,为以apoA-Ⅰ为靶点防治AS提供理论基础.Since the inverse relationship between the levels of apoA-Ⅰ in plasma and the risk of cardiovascular disease is derived from the atherosclerosis（AS）. Lipid apoA-Ⅰ formation of high-density lipoprotein（HDL）, which by promoting reverse cholesterol transport（RCT） helps cholesterol efflux. α-Helix plays an important role in cholesterol efflux, it＇s the acceptor of lipid on apoA-Ⅰ. The mimic peptides of apoA-Ⅰ have similar structure with α-helix, and they can inhibit the development of AS by different ways. This review focuses on the effects ofα-helix of apoA-Ⅰ in cholesterol efflux, in order to further explore the structure of apoA-Ⅰ influence on cholesterol efflux, aims at providing the new thought and therapy targeting for AS.

关 键 词：载脂蛋白A-Ⅰ 高密度脂蛋白 胆固醇的逆向转运 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]