Gold（Ⅰ）-Catalyzed Diastereo- and Enantioselective Synthesis of Polysubstituted Pyrrolo[3,4-d][1,2 ]oxazines  

作　　者：MeiZhang Xiaoyu Di Mingrui Zhang Junliang Zhang 

机构地区：[1]Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N, Zhongshan Road, Shanghai 200062, China [2]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2018年第6期519-525,共7页中国化学（英文版）

基　　金：We are grateful to the National Natural Science Foundation of China （21425205）, Ministry of Education of China, Ying Tung Education Foundation （121014） for financial support.

摘　　要：A gold（I）-catalyzed highly diastereo- and enantioselective intermolecular cycloaddition of oxime ethers with nitrones under mild conditions was developed, which provides an facile access to optically pure highly substituted pyrrolo[3,4-d][1,2]oxazines. The salient features of this reaction in- clude general substrate scope, high efficiency, high enantioselectivity, readily available starting materials, and the use of commercially available ligand.A gold（I）-catalyzed highly diastereo- and enantioselective intermolecular cycloaddition of oxime ethers with nitrones under mild conditions was developed, which provides an facile access to optically pure highly substituted pyrrolo[3,4-d][1,2]oxazines. The salient features of this reaction in- clude general substrate scope, high efficiency, high enantioselectivity, readily available starting materials, and the use of commercially available ligand.

关 键 词：gold（Ⅰ）-catalysis heterobicyclic pyrroles oxime ethers NITRONES tandem reaction 

分 类 号：O643.36[理学—物理化学] O614.123[理学—化学]