伴自杀观念抑郁症患者的认知功能及影响因素  

Cognitive Function and its Impact Factors of Depression Patients with Suicidal Ideation

作　　者：朱丽 杜巧荣[1] 杨春霞[1] 孙宁[1] 张爱霞[1] 李业宁 张克让[1,2] ZHU Li;DU Qiao-rong;YANG Chun-xia;SUN Ning;ZHAGN Ai-xia;LI Ye-ning;ZHAGN Ke-rang(The First Hospital of Shanxi Medical University, Taiyuan Shanxi 030001;Shanxi medical university, Taiyuan Shanxi 030001)

机构地区：[1]山西医科大学第一医院,山西太原030001 [2]山西医科大学,山西太原030001

出　　处：《世界最新医学信息文摘》2018年第9期18-20,26,共4页World Latest Medicine Information Electronic Version

基　　金：国家自然科学基金面上项目(81471379);国家精神心理疾病临床研究中心(2015BAI13B02);山西省基础研究项目青年科技研究基金(2015021204)

摘　　要：目的探讨伴与不伴自杀观念的抑郁症患者认知功能的差异及影响因素。方法采取病例对照设计,纳入172例抑郁症患者,以17项汉密顿抑郁量表自杀因子2分为界分为伴自杀观念组(71)与不伴自杀观念组(101),采用重复性成套神经心理测验和Stroop色词测验评估其认知功能,HAMD-17评估其临床症状。统计方法采用t检验,χ2检验和多因素线性回归分析。结果伴自杀观念组的即刻记忆、注意因子、延迟因子和RBANS总分均显著低于不伴自杀观念组[结果为(69.83±20.552)分,(99.86±17.750)分,(77.88±17.435)分,(76.96±13.965)分VS(77.49±21.427)分、(105.99±18.520)分、(87.26±13.401)分、(83.84±14.495)分,P<0.05],Stroop单字时间伴自杀观念组显著高于不伴自杀观念组[(14.32±5.621)VS(12.89±3.771),P<0.05]。多因素线性回归分析显示,HAMD认知障碍与注意因子呈正关联(β=—0.272)、与单字时间呈负关联(β=0.388),HAMD睡眠障碍与单字时间(β=0.246)、单色时间呈正关联(β=0.306),受教育年限与即刻记忆(β=0.439)、视觉广度(β=0.294)、注意因子(β=0.341)、RBANS总分(β=0.445)呈正关联,与单字时间呈负关联(β=—0.288),结果均达到统计学显著水平(P<0.05)。结论与不伴自杀观念的抑郁症患者相比,伴自杀观念的抑郁症患者认知功能损害更为严重,抑郁临床症状(认知障碍因子、睡眠障碍因子)和受教育年限可能是伴自杀观念抑郁症患者认知功能损害的影响因素。Objective To explore the difference of Cognitive function in depression patients with or without suicidal ideation and analysis its influence factors. Methods Taking the case control design, including 172 patients with depression, according to the 17 Hamilton depression scale, the suicide factor was divided into the suicidal ideation group（71） and the non-suicidal ideation group（101）. The cognitive function was assessed by the repetitive complete neuropsychological test and the Stroop color word test, and the clinical symptoms were assessed by HAMD-17. The statistical methods we used were independent sample t test, chi-square test and multi factor linear regression analysis. Results With suicidal ideation group of immediate memory, pay attention to the factor delay factor and RBANS Score were less with suicidal ideation group [respectively（69.83±20.552）,（99.86±17.750）,（77.88±17.435）,（76.96±13.965）]VS[（77.49±21.427）,（105.99±18.520）,（87.26±13.401）,（83.84±14.495）,（P〈0.05）], In Stroop word time,the group of suicidal ideation group was higher than the group without suicidal ideation group[（14.32±5621）VS（12.89±3.771）,（P〈0.05）]. Multi-factor linear regression analysis showed that HAMD cognitive impairment was positively associated with pay attention to the factor（β=—0.272）, and negatively associated with words time（β= 0.388）, HAMD sleep disorders（β= 0.246） with the words of time, the monochromatic time was positively related（β= 0.306）, the fixed number of year of education（β= 0.439） with immediate memory, visual range（β=0.294）, pay attention to the factor（β= 0.341）, total score on RBANS（β= 0.445） was positively related, and negatively associated with words time（β=—0.288）, the results were statistically significant（P〈0.05）. Conclusion With no suicide of depression patients, compared with suicidal ideation of the severity of cognitive function in patients with depression, depressive symptoms（cogni

关 键 词：自杀观念 抑郁症 认知功能 影响因素 

分 类 号：R749.41[医药卫生—神经病学与精神病学]