燀苦杏仁标准汤剂质量与其饮片指标成分苦杏仁苷的相关性探讨  

Explore correlation between quality of standard decoction and marker component amygdalin of decoction slices of blazing Armeniacae Semen Amarum

作　　者：张慧[1] 沈潇薇 姜慧洁 郭昱汝 汪佳楠 顾唯芝 唐岚[1] 颜继忠[1] ZHANG Hui;SHEN Xiao-wei;JIANG Hui-jie;GUO Yu-ru;WANG Jia-nan;GU Wei-zhi;TANG Lan;YAN Ji-zhong(Zhejiang University of Technology, Hangzhou 310014, China)

机构地区：[1]浙江工业大学,浙江杭州310014

出　　处：《中草药》2018年第9期2063-2069,共7页Chinese Traditional and Herbal Drugs

基　　金：浙江工业大学"省重点高校建设计划"第3批重点建设中药学学科(GY16041160006)

摘　　要：目的应用数学模型研究燀苦杏仁标准汤剂质量与其饮片中指标成分苦杏仁苷含量之间的相关性。方法制备燀苦杏仁标准汤剂,利用Design-Expert 8.0.6软件建立饮片出膏率、标准汤剂中苦杏仁苷含量、苦杏仁苷转移率分别与饮片中苦杏仁苷含量之间的3个线性回归模型。结果燀苦杏仁饮片出膏率为8.97%~12.12%;标准汤剂中苦杏仁苷含量为21.74%~30.32%;苦杏仁苷转移率为70.39%~90.54%。建立的3个线性回归模型R2均大于0.8,各项偏回归系数检验P值均小于0.05,具有显著性。3个线性回归模型均具有较好的准确性,预测值和实测值的相对偏差不大于10%,平均相对偏差不大于5%。结论该研究可预测不同燀苦杏仁饮片制备所得标准汤剂的质量,为制定其标准汤剂的质量标准提供一定参考价值。Objective To explore the relevance between the quality of standard decoction and the marker component amygdalin of decoction slices of blazing Armeniacae Semen Amarum（BASA） by mathematical model. Methods The BASA standard decoction was prepared, and three linear regression models of the amygdalin content and dry extract rate, the content of amygdalin in standard decoction and decoction slices, and the transfer rate in standard decoction and the content of amygdalin in decoction slices were established by using Design-Expert 8.0.6 software, respectively. Results The dry extract rate of BASA was 8.97%—12.12%; The content of amygdalin in standard decoction was 21.74%—30.32%; And the transfer rate of amygdalin was 70.39%—90.54%. The R2 values of three linear regression models were all greater than 0.8. The P values of each partial regression coefficient were less than 0.05, which indicated that the three models were significant. Then the accuracy of three linear regression models was verified. The relative deviation between the predicted and measured values was less than 10%, and the average relative deviation was not greater than 5%. Conclusion The models established in this study could predict the quality of standard decoction prepared from different BASA, and provide a certain reference value for the establishment of standard decoction quality standard.

关 键 词：标准汤剂 质量标准 线性回归模型 燀苦杏仁 苦杏仁苷 出膏率 转移率 

分 类 号：R286.02[医药卫生—中药学]