补体C1q/肿瘤坏死因子相关蛋白家族对心血管代谢紊乱及相关危险因素调控的研究进展  

Research advances in the regulation of cardiovascular metabolic disorders and its related risk factors by C1q/TNF related proteins

作　　者：张诗晗 杜芸辉[2] 于海存[1] 李玉明[3] 刘慧荣[1] ZHANG Shi-Han;DU Yun-Hui;YU Hai-Cun;LI Yu-Ming;LIU Hui-Rong(Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beoing 100069, China;Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Basic Medical Sciences, Yanjing Medical College, Capital Medical University, Beijing 101300, China)

机构地区：[1]首都医科大学基础医学院生理学与病理生理学系,北京100069 [2]首都医科大学附属安贞医院-北京心肺血管疾病研究所,北京100029 [3]首都医科大学燕京医学院基础医学院,北京101300

出　　处：《生理学报》2018年第3期310-318,共9页Acta Physiologica Sinica

摘　　要：补体C1q/肿瘤坏死因子相关蛋白(complement C1q/TNF related protein,CTRP)是新近发现的一类脂肪因子超家族,目前已经发现该家族有15个成员。CTRP家族成员结构均包含一个氨基末端的信号肽、一个短的可变结构域、一个胶原样结构域和一个羧基末端的球形结构域,其结构与脂联素有高度同源性,每个成员都有其独特的组织表达和多样化的功能。本文将对CTRP家族各成员的组织分布和对心血管代谢紊乱及相关危险因素如糖脂代谢异常、糖尿病的调控作一综述。The complement C1 q/TNF related protein（CTRP） family is rapidly growing and currently comprises 15 members. Although CTRP proteins share a common structure composed of four distinct domains： a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain, which is homologous to adiponectin, each CTRP has a unique tissue expression profile and varied function. In this review we focus on the biochemistry and pleiotropic functions of CTRPs as new molecular mediators regulating cardiovascular metabolic disorders and its related risk factors diseases.

关 键 词：C1q/肿瘤坏死因子相关蛋白 表达 功能 疾病 

分 类 号：R363.21[医药卫生—病理学]