不同病理类型淋巴瘤骨髓侵犯的发生率  

Incidence of Bone Marrow Involvement in Different Pathological Type Lymphoma Patients

作　　者：陈青[1,2] 朱璐婷 岑溪南 梁赜隐[1] 欧晋平[1] 王莉红[1] 王文生[1] 刘薇[1] 邱志祥[1] 董玉君[1] 王茫桔[1] 孙玉华[1] 尹玥[1] 王倩[1] 任汉云[1] CHEN Qing;ZHU Lu-Ting;CEN Xi-Nan;LIANG Ze-Yin;OU Jin-Ping;WANG Li-Hong;WANG Wen-Sheng;LIU Wei;QIU Zhi-Xiang;DONG Yu-Jun;WANG Mang-Ju;SUN Yu-Hua;YIN Yue;WANG Qian;REN Han-Yun(Department of Hematology, The First Hospital of Peking University, Beijing 100034, China;Department of Hematology, Beijing Shunyi Hospital, Beijing 101300, China)

机构地区：[1]北京大学第一医院血液科,北京100034 [2]北京市顺义区医院血液科,北京101300

出　　处：《中国实验血液学杂志》2018年第3期765-771,共7页Journal of Experimental Hematology

基　　金：北京市科委首都临床特色应用研究专项资助课题(Z141107002514017)

摘　　要：目的:分析不同病理类型淋巴瘤骨髓侵犯(BMI)的发生率。方法:回顾性分析我院2000年10月-2016年9月经组织病理确诊的702例淋巴瘤患者的骨髓检查结果。以骨髓穿刺涂片、骨髓活检、流式细胞术及^(18)F-FDG PET/CT中任何一项检查方法阳性即判定为淋巴瘤骨髓侵犯。结果:非霍奇金淋巴瘤(NHL)骨髓侵犯发生率明显高于霍奇金淋巴瘤(HL)[32.6%(201/616)vs 15%(13/86)](P<0.05)。NHL中B细胞淋巴瘤骨髓侵犯发生率明显高于T细胞淋巴瘤[37.0%(159/430)vs 22.6%(42/186)](P<0.05)。按不同病理类型分析,套细胞淋巴瘤骨髓侵犯发生率为88%(22/25),滤泡性淋巴瘤骨髓侵犯发生率为38.5%(15/39),弥漫大B细胞淋巴瘤骨髓侵犯发生率为21.8%(56/257),肝脾T细胞淋巴瘤骨髓侵犯发生率为100%(5/5)。结论:不同病理类型淋巴瘤骨髓侵犯发生率差异较大。对初诊淋巴瘤患者进行骨髓评价对淋巴瘤的分期具有重要意义。Objective： To analyze the incidence of bone marrow involvement in patients with different pathological types of lymphoma.Methods： The results of bone marrow tests including bone marrowaspiration（ BMA）,flow cytometry detection,bone marrow biopsy（ BMB） and -（18）F-FDGPET/CT,were analyzed retrospectively in 702 cases of newly diagnosed lymphoma with bone marrowassessment in our hospital from October 2000 to September 2016.If one of the above-mentioned 4 tests showed positive,the lymphoma patient was judged as bone marrow involved.Results： The incidence of bone marrow involvement（ BMI） in the patients with NHL was much higher than that in patients with HL[32.6 %（201/616） vs 15%（13/86）]（P〈0.05）.For patients with NHL,the incidence of bone marrow involvement in B-cell lymphoma was higher than that in T-cell lymphoma（ 37.0% vs 22.6%）（ P〈0.05）.According to different pathological types,the incidences of BMI in the patient with mantle cell lymphoma,hepatosplenic T-cell lymphoma,diffuse large B-cell lymphoma（ DLBCL） and follical lymphoma（ FL） were 88%（25/22）,100%（5/5）,21.8%（56/257）,and 38.5%（ 15/39）,respectively.Conclusion： The incidence of bone marrow involvement varies in different pathological types of lymphoma.Bone marrowassessment has significant importance for stading of newly diagnosed lymphoma patients.

关 键 词：淋巴瘤 骨髓侵犯 发生率 病理类型 

分 类 号：R733.1[医药卫生—肿瘤]