胃癌根治术后化疗患者血清碱性磷酸酶升高的临床意义  

Clinical significance of serum ALP elevation in patients receiving chemotherapy after radical gastrectomy

作　　者：吴有军[1] 何建苗[1] 秦荣[1] 曹志宇[1] 杨波[1] Wu Youjun;He Jianmiao;Qin Rong;Cao Zhiyu;Yang Bo.(Department of General Surgery, PLA 309th Hospital, Beijing 100091, China)

机构地区：[1]解放军第三0九医院普通外科,北京100091

出　　处：《中华普通外科杂志》2018年第6期497-499,共3页Chinese Journal of General Surgery

摘　　要：目的探讨化疗相关血清碱性磷酸酶（alkaline phosphatase，ALP）升高对胃癌根治术后患者无瘤生存时间（tumor-free survival，TFS）的影响。方法收集2010年1月至2015年12月在解放军第三。九医院普通外科接受根治性手术以及术后辅助化疗的189例胃癌患者的临床资料，采用单因素和多因素方法进行统计分析。结果血清ALP升高胃癌患者的TFS较AIJP正常胃癌患者缩短（X^2=5．717，P=0．017）。血清ALP升高是胃癌患者TFS的独立危险因素（HR=2．178，P=0．032）。血清ALP升高的程度与TFS有关（X^2=4．627，P=0．031）。结论化疗期间出现血清ALP升高提示胃癌根治术后患者复发转移的风险增加。Objective To identify the influence of chemotherapy-induced serum alkaline phosphatase （ALP） elevation on the tumor-free survival （TFS） in patients of gastric carcinoma after radical gastrectomy. Methods The clinical data of 189 gastric carcinoma patients receiving radical surgery and postoperative adjuvant chemotherapy between Jan, 2010 and Dec, 2015 were reviewed and statistically analyzed. Results The TFS of patients with serum ALP elevation was obviously inferior than those without ALP elevation （X^2 = 5. 717, P = 0. 017 ）, serum ALP elevation was an independent risk factor influencing patients＇ TFS （HR=2.178, P = 0. 032 ）, the degree of serum ALP elevation was associated with patients＇ TFS （X^2 = 4. 627, P = O. 031 ） . Conclusion Serum ALP elevation during postoperative chemotherapy indicates the increases of recurrence or metastasis rate of gastric cancer patients after radical gastrectomy.

关 键 词：胃肿瘤 碱性磷酸酶 无病生存 药物疗法 联合 

分 类 号：R735.2[医药卫生—肿瘤]