脑梗塞患者血清可溶性内皮细胞蛋白C受体和血管性假性血友病因子的表达及临床意义  

The study of serum soluble endothelial cell protein C receptors andvon Willebrand factor in cerebral infarction patients

作　　者：赵志强 崔妍妍[2] ZHAO Zhi-qiang;CUI Yan-yan(Affiliated Suzhou Hospital of Nanjing Medical University ,Clinical Laboratory Department, Suzhou 215001, China;Children＇s Hospital of Soochow University, Clinical Laboratory Depart ment , Suzhou 215003, China)

机构地区：[1]南京医科大学附属苏州医院检验科,江苏苏州215001 [2]苏州大学附属儿童医院检验科,江苏苏州215003

出　　处：《中国实验诊断学》2018年第6期970-973,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的检测血清可溶性内皮细胞蛋白C受体(sEPCR)和血管性假性血友病因子(vWF)在脑梗塞患者中的变化,探讨其在脑梗塞病情评估、诊疗效果和预后判断中的意义。方法以我院2015年1月-2016年12月收治的50例急性脑梗塞患者为研究对象,以同期50例退休体检人员为对照,采用酶联免疫吸附试验检测患者血清sEPCR和vWF水平,并对结果进行分析。结果脑梗塞患者血清sEPCR和vWF分别为(137.62±18.92)和(12.72±4.92)μg/L,较对照组显著升高(P均<0.01)。治疗后脑梗塞患者血清sEPCR和vWF水平分别为(115.43±9.42)和(9.38±3.13)μg/L,较各自治疗前显著下降(P均<0.01)。脑梗塞急性发病时患者血清sEPCR和vWF浓度越高,脑梗塞程度越重,两者呈正相关,相关系数(r)分别为0.628和0.496,P<0.05。治疗后的血清sEPCR和vWF水平越高,后遗症越重,两者表现出一定相关性,r分别为0.437和0.378,P<0.05。结论血清sEPCR和vWF水平能反映急性脑梗塞的病情轻重,对评价治疗效果、判断预后有一定参考价值。Objective To investigate the changes of plasma sEPCR and vWF in cerebral infarction patients,explore the clinical significance in disease evaluation,treatment effect and prognosis.Methods Fifty patients with acute cerebral infarction admitted in our hospital from January 2015 to December 2016 were enrolled in this study.Fifty retired men receiving physical examination were taken as the control.The sEPCR and vWF were measured by enzyme-linked immunosorbent assay（ELISA）,and the results were analyzed.Results Serum sEPCR and vWF was（137.62±18.92）and（12.72±4.92）μg/L,which was significantly higher in cerebral infarction patients than that in the control group（Pall0.01）.Plasma sEPCR and vWF levels was（115.43±9.42）and（9.38±3.13）μg/L in patients after treatment,which was much lower than that in patients before treatment（Pall0.01.The higher the concentration of serum sEPCR and vWF,the more severe the cerebral infarction was.They were positively correlated and correlation coefficients were0.628 and 0.496 respectively,P〈0.05.After treatment,the higher serum sEPCR and vWF levels,the more severe the sequelae was.They showed some correlationship and correlation coefficients were 0.437 and 0.378 respectively,P〈0.05.Conclusion The serum sEPCR and vWF can reflect to the severity of cerebral infarction and have some reference value for evaluating the therapeutic effect and judging prognosis.

关 键 词：脑梗塞 可溶性内皮细胞蛋白C受体 血管性假性血友病因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]