VEGF和Survivin在肺腺癌中的表达及意义  

Expressions and clinical significance of VEGF and Survivin in lung adenocarcinoma

作　　者：黄妙灵 蔡兴东[1] 黄志宏[1] 崔淼 梁婉玲 刘升明[1] 马洪明[1] HUANG Miao - ling;CAI Xing - dong;HUANG Zhi - hong;CUI Miao;LIANG Wan - ling;LIU Sheng - ming;MA Hong - ming(Department of Respiratory, the First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China)

机构地区：[1]暨南大学附属第一医院呼吸内科,广东广州510630 [2]暨南大学生命科学技术学院,广东广州510630

出　　处：《广东医学》2018年第12期1800-1805,共6页Guangdong Medical Journal

基　　金：国家自然科学基金青年基金项目(编号:81302030);广东省公益研究与能力建设专项基金项目(编号:2014A020212441);暨南大学科研培育与创新基金医学联合基金项目(编号:21615475)

摘　　要：目的探讨血管内皮生长因子(VEGF)和凋亡抑制蛋白生存素(Survivin)在肺腺癌患者中的表达情况及其临床意义。方法收集75例肺腺癌患者的肿瘤组织及癌旁组织标本,采用免疫组织化学SP法检测VEGF和Survivin的表达水平,并进行临床随访3~5年,分析VEGF和Survivin表达与肺腺癌患者临床特征及预后的关系。结果 VEGF在肺腺癌组织中的高表达率明显高于癌旁组织(80.00%vs 14.76%,P=0.000)。VEGF低表达肺腺癌患者5年生存率高于VEGF高表达患者(P=0.029)。Survivin在肺腺癌组织中的高表达率显著高于癌旁组织(73.33%vs 1.33%,P=0.000),并与临床分期有关(P=0.047)。Survivin低表达肺腺癌患者5年生存率较Survivin高表达患者高(P=0.032)。VEGF和Survivin共同高表达肺腺癌患者5年生存率较共同低表达者低(P=0.033),而VEGF或Survivin高表达组5年总体生存率比VEGF或Survivin低表达组低(P=0.031)。两者在肺腺癌组织中的高表达呈正相关(r=0.667,P=0.000)。单因素分析显示VEGF、Survivin和肿瘤大小、淋巴结转移、临床分期都是肺腺癌预后不良的因素,多因素分析显示VEGF表达水平和临床分期是预测肺腺癌死亡的危险因素。结论 VEGF和Survivin在肺腺癌高表达,且呈正相关,共同高表达者预后不良,可作为临床预后的预测指标。Objective To investigate the expressions and clinical significance of vascular endothelial growth factor （VEGF） and inhibitor of apoptosis protein Survivin in lung adenocarcinoma. Methods The tumor tissue and para - carcinoma tissue samples from 75 cases of lung adenocarcinoma were collected from our hospital. Immunohistochemical SP method was applied to assess VEGF and Survivin expression. The follow - up of 3 - 5 years was obtained. The correlation of the expressions of VEGF and Survivin with the clinical characteristics and the prognosis of patients with lung adenocarcinoma were analyzed. Results The high expression rate of VEGF in lung adenocarcinoma tissues was significantly higher than that in para - carcinoma tissues （80. 00% vs. 14.76%, P = 0. 000）. The 5 - year survival rate of the lung adenocarcinoma patients with low expression of VEGF was significantly higher than that of the patients with high expression of VEGF （ P = 0. 029）. The high expression rate of Survivin in lung adenocarcinoma tissues was significantly higher than that in para - carcinoma tissues （73.33% vs. 1.33% , P =0. 000）. The 5 - year survival rate of the lung adenocarcinoma pa- tients with low expression of Survivin was significantly higher than that of the patients with high expression of Survivin （ P = 0. 032）. The 5 - year survival rate of the lung adenocarcinoma patients with high expression of VEGF and Survivin was significantly lower than those with low expression （ P = 0. 033 ） ; and the 5 - year survival rate of the lung adenocarcinoma patients with high expression of VEGF or Survivin was significantly lower than those with low expression （P = 0. 031 ）. The high expression of VEGF and Survivin in the lung adenocarcinoma tissues were positively correlated （ r = 0. 667, P = 0. 000）. Univariate analysis showed that VEGF, Survivin, tumor size, lymph node metastasis and clinical stage were the risk factors of poor prognosis of lung adenocarcinoma. Multivariate analysis showed that VEGF expression and

关 键 词：肺腺癌 VEGF SURVIVIN 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]