微创锥颅术联合依达拉奉治疗对急性脑出血患者氧化应激、脑血管功能及脑氧代谢的影响  

Effect of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism,cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage

作　　者：唐杰[1] 姜学高[1] 龚玉水 叶建华[1] 黄友基[1] 黄易 黎建华[1] TANG Jie, JIANG Xue-gao, GONG Yu-shui, YE Jian-hua, HUANG You-ji, HUANG Yi, LI Jian-hua(Department of Neurosurgery, Liangshanzhou First People＇s Hospital, Xichang, Sichuan 615000, Chin)

机构地区：[1]四川省凉山州第一人民医院神经外科,四川西昌615000

出　　处：《海南医学院学报》2018年第8期873-876,共4页Journal of Hainan Medical University

基　　金：国家自然科学基金(81371345)~~

摘　　要：目的:探讨微创锥颅术联合依达拉奉治疗对急性脑出血患者脑氧代谢、脑血管功能及氧化应激的影响。方法:选取我院收治的急性脑出血患者100例,随机分为对照组与观察组,对照组50例患者给予微创锥颅术治疗,观察组50例患者在对照组的基础上给予依达拉奉联合治疗,之后对两组患者脑氧代谢、脑血管功能及氧化应激指标进行检测。结果:治疗后,两组SOD水平均显著上升,MDA水平均显著降低,且观察组治疗后SOD水平显著高于对照组,MDA水平显著低于对照组治疗后,差异有统计学意义(P<0.05);治疗后,两组患者ET水平均明显低于治疗前,CGRP水平明显高于治疗前,治疗前后对比差异均有显著性(P<0.05),且观察组治疗后ET水平显著低于对照组(P<0.05),CGRP水平显著高于对照组(P<0.05);治疗后,两组患者SjvO_2、CjvO_2及PbtO_2水平均较治疗前显著增加,DajvO_2及CEO_2水平均较治疗前显著降低,差异对比均有显著性(P<0.05),且观察组治疗后SjvO_2、CjvO_2及PbtO_2水平显著高于对照组治疗后,Da-jvO_2及CEO_2水平显著低于对照组治疗后,差异有统计学意义(P<0.05)。结论:依达拉奉联合联合微创锥颅术能有效降低患者氧化应激,改善内皮功能及脑氧代谢,疗效可靠,值得临床进一步推广应用。Objective： To investigate the effects of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage. Methods： A total of 100 patients with acute cerebral hemorrhage treated in our hospital from March 2015 to February 2017 were randomly divided into control group and observation group. 50 patients in the control group were treated with minimally invasive craniotomy. On the basis of the control groupthe observation group patients were treated with edaravone. Cerebral oxygen metabolism, cerebrovascular function and oxidative stress were measured in both groups. Results： After treatment, the levels of SOD in both groups increased significantly and MDA levels decreased significantly （ P 〈0.05）, and SOD level in the observation group was （97.34±1.95） U/ml, which was significantly higher than the control group, MDA level was （2.77±0.11）mol/L and significantly lower than that of the control group after treatment （ P 〈0.05）;After treatment, the levels of ET in both groups were significantly lower than those before treatment, and the levels of CGRP were significantly higher than those before treatment （ P 〈0.05）. ET level in observation group was （3.24±0.22） μg/L after treatment, which was significantly lower than that in control group （59.67 ±0.79） pg/mL, which was significantly higher than the control group （ P 〈0.05）;After treatment, the levels of SjvO 2, CjvO 2 and PbtO 2 in both groups were significantly increased compared with before treatment, the levels of Da-jvO 2 and CEO 2 were significantly lower than the level of before treatment （ P 〈0.05）, and the levels of SjvO 2, The levels of CjvO 2 and PbtO 2 were （62.93±1.63）%, （99.31±0.94） ml / L and （28.56±1.55） mmHg, which were significantly higher than the control group. Da-jvO 2 and CEO 2 levels were （51.31±1.13, ml/L and （30.52±0.43）%, which were significantly lower than th

关 键 词：微创锥颅术 依达拉奉 急性脑出血 脑氧代谢 脑血管功能 氧化应激 

分 类 号：R743.34[医药卫生—神经病学与精神病学]