血清胱抑素C水平与血管性认知功能障碍的相关性研究  

Relationship between serum cystatin C level and vascular cognitive impairment

作　　者：刘海涛[1] 张淑玲[1] 白宏英[2] LIU Haitao;ZHANG Shuling;BAI Hongying(Department of Neurology,Zhengzhou People＇s Hospital ,Zhengzhou 450000,China;The Second Affiliated Hospital ofZhengzhou University,Zhengzhou 450014 ,China)

机构地区：[1]郑州人民医院神经内科一病区,河南郑州450000 [2]郑州大学第二附属医院,河南郑州450014

出　　处：《中国实用神经疾病杂志》2018年第10期1057-1062,共6页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血清胱抑素C(Cys-C)水平与血管性认知功能障碍的相关性,并分析其在发生血管性认知功能障碍中的意义。方法选择2014-02-30—2017-07-30于郑州人民医院神经内科住院的110例血管性认知功能障碍患者(认知障碍组),选取同期90例健康体检者为对照组。抽取空腹静脉血5mL,使用免疫比浊法检测血Cys-C水平,比较2组一般资料及Cys C水平,分析血管性认知障碍的独立危险因素。结果 2组年龄、性别、吸烟史、高血压史、糖尿病史、TC、血肌酐、血糖、Cys-C水平差异有统计学意义(P<0.05)。血管性认知功能障碍患者年龄、TC、血肌酐、血糖、Cys-C水平,以及男性比例、吸烟史、高血压史、糖尿病史比例高于对照组。Logistic回归分析示,Cys-C、TC、高血压史、糖尿病史、年龄是血管性认知功能障碍的独立影响因素(P<0.05)。结论 Cys-C水平升高是血管性认知功能障碍的独立危险因素,高水平Cys-C可能与血管性认知功能障碍的发生具有密切关系,需进一步研究证实。Objective To investigate the relationship between the level of serum cystatin C（Cys-C）and the vascular cognitive impairment, and and analyze its significance in the development of vascular cognitive impairment.Methods From January 30, 2014 to July 30,2017,110 patients with vascular cognitive impairment who were hospitalized in the Neurology Department of Zhengzhou People＇s Hospital were selected as the cognitive impairment group,and 90 cases of health checker were selected for the same period as the control group.Five milliliter of venous blood was taken to detect the level of Cys-C by immunoturbidimetry. The general data and the level of Cys-C wer ecompared between two groups,and independent risk factors for vascular cognitive impairment were analyzed.Results The differences in age,gender,smoking history,hypertension history,diabetes history,the levels of TC,serum creatinine,blood glucose,and Cys-C were statistically significant between two groups（P 〈0.05）.The age,levels of TC,serum creatinine,blood glucose and Cys-C were higher in patients with vascular cognitive impairment than in normal patients. The proportion of male patients,smoking history,hypertension history,and diabetes history were higher in patients with vascular cognitive impairment than those in normal subjects.Logistic regression analysis showed that Cys-C , TC ,history of hypertension, history of diabetes,and age were in dependent influencing factors of vascular cognitive impairment（P 〈0.05）.Conclusion The elevated level of Cys- C is an independent risk factor for vascular cognitive impairment.High levels of Cys-C may be closely related to the occurrence of vascular cognitive impairment,which needs further research to confirm.

关 键 词：血管性认知功能障碍 血清胱抑素C 危险因素 发病机制 相关性 

分 类 号：R749.13[医药卫生—神经病学与精神病学]