促红细胞生成素治疗老年脑梗死的疗效及其对血清ox-LDL、PON1水平的影响  

The effect of erythropoietin on senile cerebral infarction and its effects on serum levels of ox-LDL and PON1

作　　者：胡明珠[1] 胡枫 HU Ming - zhu;HU Feng(Jishou People＇s Hospital, Jishou Hunan 416000, China)

机构地区：[1]湖南省吉首市人民医院急诊科,湖南吉首416000

出　　处：《临床和实验医学杂志》2018年第12期1302-1305,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨促红细胞生成素(EPO)治疗老年脑梗死的临床疗效及其对血清氧化低密度脂蛋白(oxLDL)与对氧磷酯酶-1(PON1)水平的影响。方法前瞻性将110例老年脑梗死患者按照随机数字表法分为对照组与观察组,每组患者数均为55例。两组患者均首先给予供养、脱水、降颅内压以及抗感染治疗等。观察组患者在此基础上采用EPO治疗。比较两组临床疗效、脑梗死体积、治疗前后生活质量评价量表(CIVIQ量表)评分、血清ox-LDL、PON1水平及不良反应发生率。结果经治疗,观察组临床总有效率为67.27%(37/55),显著高于对照组的52.73%(29/55)(P<0.05);观察组治疗后脑梗死体积显著小于对照组(P<0.05);两组患者治疗后CIVIQ量表各维度(社会活动、精神心理、体能以及疼痛)及总得分均分别显著高于治疗前(P<0.051),且观察组患者治疗前后上述各维度评分变化程度显著大于对照组(P<0.05);观察组患者治疗后血清ox-LDL水平显著低于治疗前及对照组患者治疗后(P<0.05),观察组患者治疗后血清PON1水平显著高于治疗前及对照组患者治疗后(P<0.05);观察组治疗后不良反应总发生率(9.09%)明显低于对照组(21.82%),差异具有统计学意义(P<0.05)。结论 EPO对老年脑梗死疗效显著,可有效减少脑梗死体积,改善生活质量,降低血清ox-LDL水平、提高PON1活性,应在临床中进行推广。Objective To investigate the clinical efficacy of EPO in treating senile cerebral infarction and its effect on serum ox-LDL and PON1 level. Methods 110 cases of elderly patients with cerebral infarction in our hospital in neurology department were randomly divided into control group and observation group,the number of patients in each group were 55 cases. Two patients were first given support,dehydration,reducing intracranial pressure,anti infection treatment. Patients in the observation group on the basis,were given EPO treatment. The cerebral infarction volume,clinical efficacy,CIVIQ score,serum ox-LDL,PON1 levels and incidence of adverse reactions of two groups were compared before and after treatment. Results After the treatment,the total clinical efficiency of the observation group was 67. 27%（ 37/55）,significantlyhigher than that of the control group 52. 73%（ 29/55）（ P〈0. 05）. The cerebral infarct volume of observation group was significantly less than that of the control group（ P〈0. 05）. CIVIQ factors（ social activities,fine God psychological,physical and pain） and total score in the two groups after treatment were significantly higher than those before treatment（ P〈0. 05）,and the scores of each dimension of variation of the observation group of patients before and after treatment was significantly greater than the control group（ P〈0. 05）. The level of serum ox-LDL after treatment was significantly lower than that before treatment and the control group patients after treatment（ P〈0. 05）. The serum level of PON1 group after treatment were significantly higher than those before treatment and control group after treatment（ P〈0. 05）. The adverse reaction incidence rate of observation group after treatment was 9. 09%（ 5/55）,and that of control group was 21. 82%（ 12/55）,with statistical significant difference（ P〈0. 05）. Conclusion The clinical efficacy of EPO is significant in elderly patients with cerebral infarction,it can effectively reduce the vol

关 键 词：老年脑梗死 促红细胞生成素 氧化低密度脂蛋白 对氧磷酯酶-1 CIVIQ量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]