结直肠癌干细胞相关标记物的研究进展  

Advances in the research of stem cell related markers for colorectal cancer

作　　者：钮仕琦 张娜[1] 刘昆 原晋阳 贾彬[2] Niu Shiqi;Zhang Na;Liu Kun;Yuan Jinyang;Jia Bin(Shanxi Medical University, Taiyuan 030001, China;Department of General Surgery, the Second Hospital of Shanxi Medical University,Taiyuan 030001, China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第二医院普外科,太原030001

出　　处：《中华普通外科学文献（电子版）》2018年第3期213-216,共4页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：结直肠癌(CRC)是胃肠道中常见的恶性肿瘤,其发病率与死亡率均位居前列。肿瘤干细胞(CSCs)是肿瘤中拥有自我更新与分化能力,可以产生异质性肿瘤细胞的细胞亚群,与结肠癌的生长、转移、耐药与不良预后有着十分密切的联系。结直肠癌干细胞(CCSCs)中相关标记物的发现对于大肠癌的早期诊断,精确寻找治疗靶点,减少肿瘤的转移与复发等有着积极的意义。本文基于近年来国内外关于CCSCs的相关研究,就其标记物、研究难点及展望作一综述。Colorectal cancer（CRC） is a common malignant tumor in the gastrointestinal tract, the incidence and mortality of which are both in the forefront. Cancer stem cells（CSCs） refer to tumor subsets that possess self-renewal and differentiation ability, can generate heterogeneous tumor cells and closely related to the growth, metastasis, drug resistance and poor prognosis of colon cancer. The discovery of biomarkers in colon cancer stem cells（CCSCs） has a positive significance in the early diagnosis of colorectal cancer, the accurate search for therapeutic targets, and the reduction of tumor metastasis and recurrence. Based on recent domestic and foreign related papers on CCSCs, a review of its markers, research difficulties and prospects is made.

关 键 词：结直肠肿瘤 肿瘤干细胞 肿瘤标记 生物学 

分 类 号：R735.34[医药卫生—肿瘤]