克罗恩病治疗的新理念  

New idea of Crohn's disease therapeutics

作　　者：巫协宁[1] 吴坚炯[1] WU Xiening,WU Jianjiong(Department of Gastroenterology, Shanghai General Hospital, Shanghai 200080, Chin)

机构地区：[1]上海市第一人民医院消化科,上海200080

出　　处：《胃肠病学和肝病学杂志》2018年第5期483-487,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：标本兼治是克罗恩病(Crohn’s disease,CD)治疗的新理念,针对其发病机制、病理生理及其病理改变进行多环节、多靶点多管齐下的中西医结合方法是我们的治疗策略。在CD中,抑制自身免疫、调节免疫、纠正Th17/Treg与Th1/Treg的失衡、抑制炎症和饮食调整是治本;抑制氧化应激、氧自由基及脂质过氧化,抑制血管新生、血管通透性、渗血以及减轻节段性肠壁厚度是治标。本文对其发病机制的每个环节加以衔接、整合,并对三联疗法的药物与食物的作用靶点作一展示。Treating both the root cause and its secondary aspects of Crohn＇s disease（CD） is a new idea. Integrating viewpoint of Chinese and Western medicine against its pathogenesis,pathophysiology and pathologic manifestations is adopted as a clinical therapeutic strategy. In CD,inhibiting and regulating the autoimmunity,correcting imbalance of Th17/Treg and Th1/Treg,ameliorating the continuous inflammation and dietary modifications are treatment of root cause,whereas inhibiting oxidation stress,free radicals and lipid peroxidation,diminishing the vascular permeability resulted in cessation of blood extravasation and alleviating the segmented intestinal wall thickness are treatment of its secondary aspects. Moreover,integration of the 6 components involved in CD pathogenesis and the multitargeting effects of food and drugs presented in the triple therapy are well defined in this article.

关 键 词：克罗恩病 标本兼治新理念 发病机制 自身免疫 三联疗法 

分 类 号：R574.62[医药卫生—消化系统]