GSTM1基因型与炎症性肠病关系的Meta分析  

Association between Glutathione S-Transferase M1 null genotype and inflammatory bowel disease: an up-date Meta-analysis

作　　者：陈影影 甄玲玲 费素娟 CHEN Yingying 1, ZHEN Lingling 1, FEI Sujuan 2(1.Graduate School, Xuzhou Medical University, Xuzhou 221000; 2.Department of Gastroenterology, the Affiliated Hospital of Xuzhou Medical University, Chin)

机构地区：[1]徐州医科大学研究生院,江苏徐州221000 [2]徐州医科大学附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2018年第5期502-506,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的系统评价谷胱甘肽S-转移酶M1(GSTM1)基因型与炎症性肠病(inflammatory bowel disease,IBD)有无相关性。方法根据纳入标准检索Pub Med、Sino Med、知网、万方、维普电子数据库,采用Review Manager 5.3软件对纳入文献进行分析。结果共13篇文献纳入研究,IBD患者4 179例,对照组8 198例。Meta分析结果显示,GSTM1基因型与IBD患者有相关性(OR=1.32,95%CI:1.09~1.61,P<0.05)。人种亚组分析显示,亚洲人群GSTM1(-)基因型是IBD的遗传高风险因素(OR=2.57,95%CI:1.85~3.57,P<0.05);但在高加索人中,GSTM1(-)基因型与IBD无明显相关性(OR=1.03,95%CI:0.94~1.12,P>0.05)。此外,GSTM1(-)基因型增加了溃疡性结肠炎(ulcerative colitis,UC)的易感性(OR=1.46,95%CI:1.09~1.96,P<0.05);但GSTM1(-)基因型与克罗恩病(Crohn’s disease,CD)无明显相关性(OR=1.09,95%CI:0.90~1.33,P>0.05)。结论 GSTM1(-)基因型增加了IBD的遗传易感性,是UC的危险因素,但与CD无明显相关性。在亚洲人中,GSTM1(-)基因型是IBD的遗传高风险因素,但在高加索人中无明显相关性。Objective To systematically evaluate whether there was association between Glutathione S-Transferase M1（GSTM1） null genotype and inflammatory bowl disease（IBD）. Methods We searched 5 online databases according to the included standards. The studies were analyzed by Review Manager 5. 3. Results There were 13 studies included in the Meta-analysis. There were 4 179 cases with IBD and 8 198 controls. The Meta-analysis showed the GSTM null genotype was associated with the susceptibility of IBD（OR = 1. 32,95% CI： 1. 09-1. 61,P〈0. 05）. The subgroup analysis by ethnicity showed an association between the GSTM1 null genotype and IBD in Asians,and the difference was statistically significant（OR = 2. 57,95% CI： 1. 85-3. 57,P〈0. 05）. But the difference was not statistically significant in Caucasians（OR = 1. 03,95% CI： 0. 94-1. 12,P〈0. 05）. The GSTM1 null genotype was also associated with ulcerative colitis（UC）,and the difference was statistically significant（OR = 1. 46,95% CI： 1. 09-1. 96,P〈0. 05）. But the difference was not statistically significant in Crohn＇s disease（CD）（OR = 1. 09,95% CI： 0. 90-1. 33,P〈0. 05）. Conclusion GSTM1 null genotype increases the susceptibility of IBD and it is a risk factor for UC.Meanwhile,the GSTM1 null genotype is a risk factor for Asians,but there is no correlation with Caucasians.

关 键 词：谷胱甘肽S-转移酶M1 基因多态性 炎症性肠病 

分 类 号：R574.62[医药卫生—消化系统]