c-Met及Notch-1对非小细胞肺癌患者预后的影响  

The prognostic value of c-Met and Notch-1 in non-small cell lung cancer patients

作　　者：金子[1] 马锐 于若曦 邹丹 王希明[3] 蔡颖[1] 宋慧聪 吕飞 隋丹 张晔[1] Jin Zi;Ma Rui;Yu Ruoxi;Zou Dan;Wang Ximing;Cai Ying;Song Huicong;Lv Fei;Sui Dan;Zhang Ye(Department of Medical Oncology;3.Department of Respiratory and Infectious Disease of Geriatrics,the First Hospital of China Medical University,Liaoning Shenyang 110001,Chin;2.The Second Department of Thoracic Medicine,Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute,Liaoning Shenyang 110042,China)

机构地区：[1]中国医科大学附属第一医院肿瘤内科,辽宁沈阳110001 [2]中国医科大学肿瘤医院,辽宁省肿瘤医院胸内二科,辽宁沈阳110042 [3]中国医科大学附属第一医院干诊呼吸科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2018年第11期1692-1696,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81270036,30901736);辽宁省重点研发计划攻关项目(编号:2017225029);沈阳市科技计划项目(编号:18-014-4-11);中国医科大学附属第一医院科学研究基金(编号:FHCMU-FSR)

摘　　要：目的:通过检测c-Met及Notch-1在非小细胞肺癌(non-small cell lung cancer,NSCLC)手术切除患者中的表达,探究其对患者预后的影响。方法:应用免疫组化方法检测收集到的106例NSCLC石蜡标本中c-Met和Notch-1的表达情况,分析c-Met和Notch-1表达与患者预后之间的关系。结果:c-Met表达与N分期、p TNM分期相关,Notch-1表达与N分期相关。c-Met和Notch-1阳性表达的患者均较阴性表达患者预后差(P<0.001)。相关分析显示,c-Met与Notch-1正相关(P<0.001)。c-Met与Notch-1联合分析发现,双阳性组患者预后最差,单阳性组其次,双阴性组最佳(P<0.001)。COX单因素分析发现,c-Met、Notch-1、T分期、N分期、p TNM分期是预后的风险因素。进一步COX多因素分析,结果显示c-Met表达为预后的独立风险因素(P<0.001),而Notch-1表达与预后无关(P=0.732)。结论:c-Met及Notch-1联合检测可更精确的预测NSCLC患者预后风险。Objective：To examine the expression of c-Met and Notch-1 in patients with non-small cell lung cancer（ NSCLC） and explore their effect on the prognosis of patients.Methods：A total of 106 cases of NSCLC paraffin-embedded specimens were collected to detect the expression of c-Met and Notch-1 by immunohistochemistry.Results：The expression of c-Met was correlated with N stage and p TMN stage,and Notch-1 expression was associated with N stage.The prognosis was worse in patients with positive expression of c-Met and Notch-1 than those with negative expression,respectively（ P〈0.001）.Correlation analysis showed that c-Met was positively correlated with Notch-1（ P〈0.001）.The combination analysis of c-Met and Notch-1 showed that the prognosis of the double positive group was the worst,while the double negative group was the best（ P〈0.001）.COX univariate analysis of clinical parameters showed that c-Met,Notch-1,T stage,N stage,p TNM stage were prognostic factors.COX multivariate analysis showed that c-Met expression was the independent prognostic risk factor（ P〈0.001）,while Notch-1 expression was not associated with prognosis（ P = 0.732）.Conclusion：The combination of c-Met and Notch-1 could predict the prognosis of patients more accurately.

关 键 词：C-MET NOTCH-1 免疫组化染色 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]