基质金属蛋白酶-9基因rs3918242位点多态性与胃癌易感性的Meta分析  

Matrix Metalloproteinase-9 Gene rs3918242 Polymorphisms Increase the Risk of Gastric Cancer: a Meta-analysis

作　　者：张焕鑫 袁平 赵继先 李波 王家宁 唐俊明 沈俊 ZHANG Huan-xin;YUAN Ping;ZAHO Ji-xian;LI Bo;WANG Jia-ning;TANG Jun-ming;SHEN Jun(Department of Cardiology;Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China)

机构地区：[1]湖北医药学院附属人民医院心内科1病区,湖北十堰442000 [2]湖北医药学院附属人民医院临床医学研究所,湖北十堰442000

出　　处：《湖北医药学院学报》2017年第6期491-495,500,共6页Journal of Hubei University of Medicine

基　　金：国家自然科学基金(81270221,81170095);湖北省自然科学基金(2014CFB644)

摘　　要：目的:采用Meta分析评估基质金属蛋白酶-9(MMP-9)基因多态性对胃癌遗传易感性的影响。方法:通过PubMed、Embase、CNKI和万方数据库(至2017年5月17日)检索相关研究。采用Stata 12.0进行统计学分析,计算合并比值比(odds ratio,OR)及95%可信区间(confidence interval,CI),使用Q检验和I2值评估研究之间的异质性,并进行亚组分析、敏感性分析和发表偏倚检测。结果:最后纳入7项研究,纯合子模型TT vs.CC(OR=1.70,95%CI=1.06~2.72,P=0.027),隐性模型TT vs.CC+CT(OR=1.74,95%CI=1.22~2.71,P=0.01)两种基因模型下均观察到显著相关性,差异有统计学意义;T vs.C,CT vs.CC,CT+TT vs.CC三种基因模型与胃癌无显著相关性,差异无统计学意义。亚组分析和敏感性分析显示结果真实可靠。结论:该Meta分析表明,MMP-9-1562 C>T多态性与胃癌易感性明显相关,TT基因型携带者的胃癌易感性高于CC人群和CC+CT人群。受纳入研究数量和质量限制,尚需开展大样本、高质量的随机对照试验进一步论证上述结论。Objective Meta-analysis was performed to evaluate the effect of MMP-9 gene polymorphism on the genetic susceptibility of gastric cancer. Methods Related researches were recognized by searching PubMed,Embase,CNKI and Wanfang databases（ until May 17,2017）. Odds ratio（ OR） and 95% confidence interval（ CI） were calculated and analyzed using Stata 12.0 software,and heterogeneity between studies were assessed using the Q test and I^2 value. The Begg＇s funnel plot and Egger＇s test were performed to evaluate the publication bias of literatures. Results Finally seven relative reports on MMP-9-1562 CT（ rs3918242） were included. For MMP-9-1562 CT,significant association was observed under two genetic models in the overall（ TT vs.CC; TT vs.CC＋CT）,however,the non-significantly increased risk was shown in T vs.C,CT vs.CC,CT＋TT vs.CC. Subgroup analysis and sensitivity analysis showed that the results were reliable. Publication bias was not detected by either funnel plot or Egger＇s tests. Conclusion This meta-analysis suggested that MMP-9-1562 CT polymorphism was significantly associated with increased risk of gastric cancer. Patients with TT genotype had higher gastric cancer susceptibility than those with CC and CC ＋ CT. Owing to the quantity and quality limitations of the included studies,a large sample and high quality randomized controlled trial are needed to further demonstrate the above conclusions.

关 键 词：基质金属蛋白酶-9 基因多态性 胃癌 META分析 

分 类 号：R735.2[医药卫生—肿瘤]