宁夏泾源县非酒精性脂肪性肝病的患病率及其危险因素调查  

Epidemiological study of nonalcoholic fatty liver disease in Jingyuan county of Ningxia Autonomous Region

作　　者：路青玲 王婷[2] 张海东 薛海莉 王金莲 李道艳 赵威 杨永利 马成虎 侯旭宏[9] 孙庆毅[9] 贾伟平[9] 何兰杰 Lu Qingling;Wang Ting;Zhang Haidong;Xue Haili;Wang Jinlian;Li Daoyan;Zhao Wei;YangYongli;Ma Chenghu;Hou Xuhong;Sun Qingyi;Jia Weiping;He Lanfie(Department of Physical Examination, Cardio-Cerebral Vascular Disease Hospital of Ningxia Medical University, Yinchuan 750000, Chin;Department of Health Management Center, General Hospital of Ningxia Medical University, Yinchuan 750000, Chin;Medical Department, Cardio-Cerebral Vascular Disease Hospital of Ningxia Medical University, Yinchuan 750000, Chin;Preventive Medicine Department, Cardio-Cerebral Vascular Disease Hospital of Ningxia Medical University, Yinchuan 750000, Chin;Medical Record Department, Cardio-Cerebral Vascular Disease Hospital of Ningxia Medical University, Yinchuan 750000, China;Ultrasonography Department, Cardio-Cerebral Vascular Disease Hospital of Ningxia Medical University, Yinchuan 750000, Chin;Liu Panshan Township Health Center in Jingyuan County, Ningxia Province, Guyuan 756400, China;Da Wan Township Health Center in Jingyuan County, Ningxia, Guyuan 756400, Chin;Department of Endocrinology and Metabolism, Shanghai Sixth People＇s Hospital, Shanghai Jiao Tong University, Shanghai 200233, Chin;epartment of Endocrinology, Qilu Hospital of Shandong Universit;ingdao 266035, Chin)

机构地区：[1]宁夏医科大学总医院心脑血管病医院健康体检科,银川750000 [2]宁夏医科大学总医院健康管理中心,银川750000 [3]宁夏医科大学总医院心脑血管病医院医教科,银川750000 [4]宁夏医科大学总医院心脑血管病医院预防保健科,银川750000 [5]宁夏医科大学总医院心脑血管病医院病案室,银川750000 [6]宁夏医科大学总医院心脑血管病医院B超室,银川750000 [7]宁夏固原市泾源县六盘山镇卫生院,固原756400 [8]宁夏固原市泾源县大湾乡卫生院,固原756400 [9]上海交通大学附属第六人民医院内分泌代谢科,上海200233 [10]山东大学齐鲁医院青岛分院内分泌科,青岛266035

出　　处：《中华健康管理学杂志》2018年第3期237-242,共6页Chinese Journal of Health Management

基　　金：宁夏回族自治区发改委重大项目（2012-1）;国家重点基础研究发展计划（2011CB504000）

摘　　要：目的了解宁夏泾源县非酒精性脂肪性肝病（NAFLD）的患病率及其危险因素。方法采用人口比例抽样法，对泾源县18岁以上居民10639人进行问卷调查、体格检查、收集空腹静脉血检测血糖、血脂、血尿酸，排除数据缺失纳入分析的共10553人。采用高分辨率超声仪进行肝脏检查。根据肝脏超声检查结果，将研究对象分为NAFLD组和正常组，采用χ2检验比较两组血液生化指标的差异，采用多因素Logostic回归模型探讨影响NAFLD患病的危险因素。结果NAFLD的总患病率为7.60%，男性（8.60%）高于女性（6.82%）（χ2=11.772，P=0.001）。NAFLD患病率随年龄增长而增高（χ2=57.336，P〈0.001），18岁-，30岁-，40岁-，50岁-，60岁-，70岁-组NAFLD患病率分别为2.92%、6.50%、8.81%、9.59%、8.08%、4.77%；NAFLD组超重、肥胖、腹型肥胖、空腹血糖调节受损、糖耐量异常、糖尿病、高血压、高尿酸血症、血脂异常的检出率均高于正常组（P均〈0.05）。Logistic回归分析显示，超重、肥胖、腹型肥胖、空腹血糖调节受损、糖耐量异常、糖尿病、高血压、高尿酸血症、血脂异常人群患NAFLD的风险分别升高5.41、12.45、2.99、1.85、2.05、3.30、1.41、2.23、1.98倍。结论宁夏泾源县NAFLD患病率较高，超重、肥胖、腹型肥胖、空腹血糖调节受损、糖耐量异常、糖尿病、高血压、高尿酸血症、血脂异常人群的NAFLD患病风险较正常人群高。ObjectiveTo investigate the prevalence of nonalcoholic fatty liver disease and the risk factors in Jingyuan county of Ningxia Autonomous Region.MethodsThe population proportionate sampling method was applied to enroll a representative sample of 10 639 adults in Jingyuan county and the study was conducted using questionnaires and physical examinations. A total of 10 553 people were included in the analysis after excluding those with missing data. High-resolution ultrasound was used to examine the liver and fasting blood was collected in the morning for measurement of blood glucose, blood lipid, and uric acid. The participants were divided into two groups of those with and without nonalcoholic fatty liver disease; the difference in blood biochemical indexes between fatty liver and non-fatty liver groups was compared, and the logistic regression model was used to explore the risk factors affecting the prevalence of fatty liver.ResultsThe prevalence of nonalcoholic fatty liver disease was 7.60%. The prevalence of thyroid nodules was higher in men than in women （8.60% vs. 6.82%, χ2=11.772, P=0.001）. The prevalence rate of fatty liver increased with age （χ2=57.336, P〈0.001）, the prevalence rates among ≥18 years-〈29 years, ≥30 years-〈39 years, ≥40 years-〈49 years, ≥50 years-〈59 years, ≥60 years-〈69 years, and above 70 years were 2.92%, 6.50%, 8.81%, 9.59%, 8.08%, and 4.77% respectively. The detection rate of overweight, obesity, abdominal obesity, impaired fasting glucose, impaired glucose tolerance, diabetes, hypertension, hyperuricemia, and dyslipidemia were higher in nonalcoholic fatty liver disease group than in the normal group （P〈0.05）. Logistic regression analysis showed that nonalcoholic fatty liver disease group had a higher risk for overweight, obesity, abdominal obesity, impaired fasting glucose, impaired glucose tolerance, diabetes, hypertension, hyperurcemia, and dyslipidemia （OR=5.41, 12.45, 2.99, 1.85, 2.05, 3.30, 1.41, 2.23, and 1.98）.ConclusionThe incidence of n

关 键 词：脂肪肝 患病率 

分 类 号：R575.5[医药卫生—消化系统]