食管癌根治术中应用右美托咪定麻醉对患者术后认知功能的影响  

Effect of dexmedetomidine anesthesia on postoperative cognitive function in patients undergoing radical resection of esophageal carcinoma

作　　者：张永[1] 齐光辉 蒋鹏 王宁军 王静 崔慧敏[2] ZHANG Yong;QI Guanghui;JIANG Peng(Huaxian People＇s Hospital, Anyang 456400, Chin)

机构地区：[1]滑县人民医院,安阳456400 [2]河南省濮阳市人民医院

出　　处：《国际精神病学杂志》2018年第3期528-530,共3页Journal Of International Psychiatry

摘　　要：目的探讨右美托咪定对食管癌根治术全麻患者术后认知功能的影响。方法将76例食管癌根治术全麻患者随机分为2组,每组各38例,两组均给予芬太尼持续静脉泵入镇痛,对照组予以力月西麻醉,观察组予以右美托咪定麻醉,比较两组镇静效果,认知功能和不良反应发生率。结果两组镇静效果时间无显著性差异比较(P>0.05);但观察组停药后苏醒时间短于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。观察组治疗后威斯康辛卡片分类测验(WCST)总应答数、持续性错误数、非持续性错误数显著低于对照组,正确应答数、完全分类数显著多于对照组,差异具有统计学意义(P<0.05)。结论与力月西比较,右美托咪定用于食管癌根治术全麻中的镇静效果好,对患者认知功能影响较小,且不良反应发生率低。Objective To investigate the effect of dexmedetomidine on postoperative cognitive function in patients undergoing radical resection of esophageal carcinoma. Methods 76 cases of radical resection of esophageal cancer patients were randomly divided into 2 groups, 38 cases in each group. Both two groups were given fentanyl intravenous analgesia, the control group were given midazolam for anesthesia, and the observation group were given dexmedetomidine for Anesthesia. effect, postoperative cognitive function and adverse reaction were compared between the two groups. Results The sedative effect of time between the two groups were no statistically significant difference （ P〉0.05 ）; but t the recovery time in the observation group was shorter than that in the control group （ P〈0.05 ）; the incidence of adverse reactions in the observation group was lower than that in the control group （P 〈 0.05 ） . The WCST total responses, persistent error number, non-persistent error number in the observation group after treatment were significantly lower than those in the control group, and the correct responses, a completed classification number were more than those in the control group, the differences above were statistically significant （P〈 0.05 ） . Conclusion Compared with anesthesia of midazolam, the anesthesia effect of dexmedetomidine in general anesthesia for esophageal cancer sedation is better, and it has less influence on the cognitive function of patients, and the incidence of adverse reactions is lower as well.

关 键 词：食管癌根治术 全麻 右美托咪定 力月西 认知功能 

分 类 号：R749.9[医药卫生—神经病学与精神病学]