周围神经损伤后促红细胞生成素、他克莫司、维生素B_(12)及甲强龙对神经再生的作用  

Effects of erythropoietin, tacrolimus, vitamin B_(12) and methylprednisolone on nerve regeneration after peripheral nerve injury

作　　者：李涛[1] 董传江[1] LI Tao;DONG Chuan-jiang(Department of Urology, the First Clinical Medical College of China Three Gorges University, Yichang 443000, Hubei, CHIN)

机构地区：[1]三峡大学第一临床医学院泌尿外科,湖北宜昌443000

出　　处：《海南医学》2018年第12期1735-1738,共4页Hainan Medical Journal

基　　金：国家自然科学基金(编号:8130062)

摘　　要：目前外伤源性神经损伤很常见,中枢神经细胞损伤后几乎不可能再生。而周围神经受损后的恢复效果受神经损害程度、包裹受损神经周围组织的营养状态、血液供应情况、神经连接处瘢痕、患者年龄、有无合并颅脑外伤、神经显微手术效果及药物的合理运用等多种内外因素影响。虽然现在已公认神经显微手术对周围神经修复起着关键性作用,但研究同时也表明促红细胞生成素(erythropoietin,EPO)、他克莫司(FK506)、维生素B_(12)(vitamin B_(12))及甲强龙(methylprednisolone,MP)对损伤后的周围神经不仅具有保护作用,还可促进断裂神经再生。本文对这些药物在神经损伤后对神经的保护和促进再生作用机制进行综述。At present, traumatic nerve injury is very common, and the central nerve cells can hardly regenerate after injury. The effect of recovery of damaged peripheral nerve is affected by nerve damage, nutrition status of the tissue surrounding the damaged nerve, blood supply, scar at nerve connections, age, complication of craniocerebral trauma, effect of nerve microsurgery, and rational application of drugs. Although microsurgery plays an important role in the repair of peripheral nerves, drugs, such as erythropoietin（EPO）, tacrolimus（FK506）, Vitamin B（12）, and methylprednisolone（MP）, are also proved to be effective in protecting peripheral nerves and promoting nerve regeneration. This review summarizes the effect and the mechanisms of these drugs.

关 键 词：促红细胞生成素 他克莫司 维生素B12 甲强龙 神经再生 

分 类 号：R745[医药卫生—神经病学与精神病学]