苓术二陈汤联合西药治疗非酒精性脂肪性肝病(痰湿内停)随机平行对照研究  

Randomized Controlled Parallel Study of Ling Shu Erchen Decoction(苓术二陈汤) combined with Western Medicine in the Treatment of Nonalcoholic Fatty Liver Disease(Tanshi Neiting/痰湿内停)

作　　者：郭宗超 GUO Zongchao(Neurology Department of Ruzhou people＇s Hospital,Ruzhou 467500 Henan,Chin)

机构地区：[1]汝州市人民医院神经内科,河南汝州467500

出　　处：《实用中医内科杂志》2018年第5期33-36,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察苓术二陈汤联合西药治疗非酒精性脂肪性肝病(痰湿内停)疗效。[方法]使用随机随机平行对照方法,将80例门诊患者按就诊顺序编号方法简单随机分为两组。对照组40例熊去氧胆酸,8~l0mg/kg·d^(-1),2次/d,进餐时服用;普伐他汀钠,起始剂量:10~20mg/次,1次/d,之后根据根据症状调整剂量,最高≤40mg/d,睡前服用。治疗组40例苓术二陈汤(茯苓、白术各12g,半夏^(法)10g,陈皮、橘红各15g,乌梅、生姜、甘草各6g),水煎400m L,1剂/d,早晚口服;西药治疗同对照组。连续治疗2个月为1疗程。观测临床症状、谷丙转氨酶、谷草转氨酶、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、肝脾CT比、不良反应。治疗1疗程(2个月),判定疗效。[结果]治疗组临床痊愈13例,显效9例,有效14例,无效4例,总有效率90.00%;对照组临床痊愈7例,显效10例,有效14例,无效9例,总有效率77.50%;临床疗效两组无显著差异(P>0.05);ALT、AST两组均有降低(P<0.01),治疗组降低多于对照组(P<0.05,P<0.01);TC、TG、HDL-C、LDL-C两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01);肝脾CT比值两组均有增加(P<0.05),治疗组增加大于对照组(P<0.01)。[结论]苓术二陈汤联合西药治疗非酒精性脂肪性肝病(痰湿内停),疗效满意,无严重不良反应,值得推广。[Objective] To observe the curative effect of Ling Shu Erchen decoction（苓术二陈汤） combined with western medicine on non-alcoholic fatty liver disease（Tanshi Neiting/痰湿内停）. [Methods] Using random parallel control method,80 outpatients were randomly divided into two groups according to the order number method. In the control group,40 cases of ursodeoxycholic acid,8 to l0 mg/kg·d^-1,2 times/d,were taken at meals; pravastatin sodium was used as the initial dose：10-20 mg/times and 1 times/d,then the dosage was adjusted according to the symptoms,the maximum was less than 40 mg/d,before bedtime. In the treatment group,40 cases of two Chen Tang（Fuling,Baizhu each 12 g,Banxia 10 g,Chenpi,Juhong each 15 g,Wumei,Shengjiang,Gancao each 6 g）,decoction 400 mL,1 Ji/d,were taken orally in the morning and evening; western medicine was treated with the control group. Continuous treatment for 2 months was the 1 course of treatment. The clinical symptoms,alanine aminotransferase,glutamate transaminase,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,CI ratio of liver and spleen,and adverse reactions were observed. The 1 course of treatment（2 months） was treated and the curative effect was determined. [Results] In the treatment group,13 cases were cured,9 cases were markedly effective,14 cases were effective,4 cases were invalid,the total effective rate was 90%,7 cases in the control group,10 cases,14 effective,9 cases,9 cases,and 77.50% total effective rate（P〈0.05）; ALT and AST two groups were reduced（P〈0.01）,and the treatment group decreased. More than the control group（P〈0.05,P〈0.01）,TC,TG,HDL-C,LDL-C two groups were improved（P〈0.05,P〈0.01）,the treatment group was better than the control group（P〈0.05,P〈0.01）,the liver spleen CT ratio two groups were increased（P〈0.05）,the treatment group increased more than the control group（P〈0.01）. [Conclusion] Ling Shu Erchen decoction combined with western med

关 键 词：非酒精性脂肪性肝病 胁痛 痰湿内停 苓术二陈汤 熊去氧胆酸 普伐他汀钠 谷丙转氨酶 谷草转氨酶 总胆固醇 甘油三酯 高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 肝脾CT比 中药复方 随机平行对照研究 

分 类 号：R575.5[医药卫生—消化系统]