伴皮脂腺增生的结缔组织增生性毛发上皮瘤一例  

Desmoplastic trichoepithelioma complicated by sebaceous hyperplasia： a case report

作　　者：甘中华 唐波 王洪飞 高杰 Can Zhonghua;Tang Bo;Wang Hongfei;Gao Jie(Department of Pathology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, Sichuan, Chin)

机构地区：[1]西南医科大学附属中医医院病理科,四川泸州646000

出　　处：《中华皮肤科杂志》2018年第7期529-530,共2页Chinese Journal of Dermatology

摘　　要：患者男，67岁，因头顶部皮损1年余来院就诊。体检：头顶部一淡红色环形斑块，约1．5cm×1cm，中央凹陷，边缘见淡黄色丘疹样突起，表面无毛发生长。皮损组织病理检查：表皮轻度增生，表面部分区域凹陷，真皮内见多个皮脂腺融合增生；真皮浅层见较多条索状嗜碱性上皮细胞及角囊肿，周围胶原纤维明显增生。免疫组化结果：CD34阳性（毛源性间质），上皮膜抗原、细胞角蛋白20阳性，bel-2、P53、CD56、1W型胶原纤维均阴性，增殖指数Ki672％～5％。病理诊断：结缔组织增生性毛发上皮瘤伴皮脂腺增生。A 67-year-old male patient presented with a plaque on the top of the head for more than 1 year. Physical examination showed an annular pale red plaque sized about 1.5 cm x 1 cm on the top of the head. It had a depressed center and papule-like elevated faint yellow boundaries, and there was no hair on the surface of the lesion. Histopathologic examination revealed milder epidermal hyperplasia, a small area of epidermal depression, confluence and hyperplasia of multiple sebaceous glands in the dermis, many keratinous cysts and funicular basophilic epithelial cells surrounded by hyperplastic collagen fibers in the superficial dermis. Immunohistochemical study showed positive staining for CD34 （hair mesenchymal cells）, epithelial membrane antigen （EMA）, cytokeratin 20 （CK20）, but negative staining for bcl-2, P53, CD56 and collagen IV, with the proliferation index Ki-67 of 2% - 5%. Based on the pathological results, the patient was diagnosed with desmoplastic trichoepithelioma complicated by sebaceous hyperplasia.

关 键 词：皮脂腺疾病 结缔组织增生性毛发上皮瘤 

分 类 号：R739.5[医药卫生—肿瘤]