创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望  

Characteristics and research prospects of cerebral metabolism in patients with traumatic brain injury

作　　者：韦博[1] 李朝晖[1] WEI Bo;LI Zhaohui(Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, 130031, China)

机构地区：[1]吉林大学中日联谊医院神经外科,长春130031

出　　处：《第三军医大学学报》2018年第13期1161-1165,共5页Journal of Third Military Medical University

基　　金：吉林省卫生计生青年科研课题(2015Q005)~~

摘　　要：创伤性颅脑损伤（traumatic brain injury,TBI）是发达国家40岁以下人群中死亡的主要因素。TBI发生后的继发性脑损伤是影响预后的重要因素,如何尽早发现和持续监测继发性脑损伤并及时采取治疗措施是临床重大的挑战（[1]）。脑能量代谢障碍是TBI发生后重要的病理生理改变之一.Cerebral metabolism failure is one of the most important pathophysiological changes after traumatic brain injury （TBI）. The energy metabolism disorder following TBI is associated with failure to maintain normal ionic homeostasis, excitotoxic releases of glutamate and other excitatory neurotransmitters, free radicals damage, and mitochondrial dysfunction. There are several methods to measure cerebral metabolism, including jugular bulb catheter, cerebral microdialysis （CMD）, positron emission tomography （PET）, and magnetic resonance spectroscopy （MRS）. It is of great importance to monitor cerebral metabolism in the TBI patients in order to evaluate the severity of brain injury, predict the risk for development of secondary cerebra injury, guide systemic glucose management, assess the ability of nerve repair, and so on. Monitoring cerebral metabolism has been an important part of muttimodal monitoring in severe neurological patients.

关 键 词：创伤性颅脑损伤 脑能量代谢 脑微透析 

分 类 号：R364.2[医药卫生—病理学] R651.15[医药卫生—基础医学]