Phytochemical-encapsulated nanoplatform for ＂ondemand＂ synergistic treatment of multidrug-resistant bacteria  

作　　者：Panpan Sun Yan Zhang Xiang Ran Chaoying Liu Zhenzhen Wang Jinsong Ren Xiaogang Qu 

机构地区：[1]State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China [2]Department of Respiratory Medicine, First Affiliated Hospital, Jilin University, Changchun 13002 I, China [3]University of Science and Technology of China, Hefei 230029, China

出　　处：《Nano Research》2018年第7期3762-3770,共9页纳米研究（英文版）

基　　金：support from the National Natural Science Foundation of China （Nos. 21210002, 21431007, 21533008, 21403209, 21601175, and 21673223） and the Jilin Province Science and Technology Develop- ment Plan Project （No. 20140101039JC）.

摘　　要：Though phytochemicals are a promising alternative to traditional antibiotics for combating resistant bacteria, the low water solubility and lack of selectivity seriously hinder their widespread applications. Herein, we constructed a hyaluronidase-activated ＂on-demand＂ delivery nanocarrier to encapsulate plant essential oils （PEOs） for the synergistic treatment of mulfidrug-resistant bacteria. The bioavailability and selectivity of PEOs was enhanced and the antibacterial effect was significantly improved by combining with the photothermal effect of the nanocarrier. This antibacterial system was successfully applied for healing methicillin-resistant Staphylococcus aureus-infected wound with negligible cytotoxicity and biotoxicity in mice. Given the increasing risk of antibiotic resistance, we believe that this phytochemical-encapsulated nanoplatform would provide a long-term solution and be a new powerful tool for skin-associated bacterial infections.Though phytochemicals are a promising alternative to traditional antibiotics for combating resistant bacteria, the low water solubility and lack of selectivity seriously hinder their widespread applications. Herein, we constructed a hyaluronidase-activated ＂on-demand＂ delivery nanocarrier to encapsulate plant essential oils （PEOs） for the synergistic treatment of mulfidrug-resistant bacteria. The bioavailability and selectivity of PEOs was enhanced and the antibacterial effect was significantly improved by combining with the photothermal effect of the nanocarrier. This antibacterial system was successfully applied for healing methicillin-resistant Staphylococcus aureus-infected wound with negligible cytotoxicity and biotoxicity in mice. Given the increasing risk of antibiotic resistance, we believe that this phytochemical-encapsulated nanoplatform would provide a long-term solution and be a new powerful tool for skin-associated bacterial infections.

关 键 词：multidrug-resistant bacteria NANOCARRIERS ON-DEMAND synergistic treatment 

分 类 号：TQ462[化学工程—制药化工] TP316.81[自动化与计算机技术—计算机软件与理论]