Nanomaterial-assisted sensitization of oncotherapy  

作　　者：Yufei Wang Juan Liu Xiaowei Ma Xing-Jie Liang 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China [2]University of Chinese Academy of Sciences, Beijing 100049, China [3]Tissue Engineering Lab, Beijing Institute of Transfusion Medicine, Beijing 100850, China

出　　处：《Nano Research》2018年第6期2932-2950,共19页纳米研究（英文版）

摘　　要：Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. Conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cancer. However, along with their wide usage, limited therapeutic effects, severe adverse reactions, unaffordable costs, and complicated operations lead to failures of these treat- ments. Moreover, the emergence of multidrug resistance inhibits the longtirne usage of chemotherapeutics. One of the major causes of treatment failure is the insufficient sensitivity of cancer cells to therapeutic drugs or treatments. With the rigorous development of nanotechnolog~ tailored nanoparticles can efficiently sensitize malignant cells by inducing intracellular structural and functional changes, which could affect vital intracellular processes such as metabolism, signal conduction, proliferation, cell death as well as intracellular drug delivery. Here, we review recent advances in nanomaterial-assisted sensitization of oncotherapy, and challenges and strategies in the development of nanomedical approaches.Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. Conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cancer. However, along with their wide usage, limited therapeutic effects, severe adverse reactions, unaffordable costs, and complicated operations lead to failures of these treat- ments. Moreover, the emergence of multidrug resistance inhibits the longtirne usage of chemotherapeutics. One of the major causes of treatment failure is the insufficient sensitivity of cancer cells to therapeutic drugs or treatments. With the rigorous development of nanotechnolog~ tailored nanoparticles can efficiently sensitize malignant cells by inducing intracellular structural and functional changes, which could affect vital intracellular processes such as metabolism, signal conduction, proliferation, cell death as well as intracellular drug delivery. Here, we review recent advances in nanomaterial-assisted sensitization of oncotherapy, and challenges and strategies in the development of nanomedical approaches.

关 键 词：NANOMATERIAL ONCOTHERAPY sensitization of oncotherapy mulfidrug resistance 

分 类 号：TE626.24[石油与天然气工程—油气加工工程] TQ174.759[化学工程—陶瓷工业]