云南高校图书馆联盟文献共享服务平台- ONCOTHERAPY

ONCOTHERAPY: 作品数：11被引量：9H指数：2; 导出分析报告; 相关领域：医药卫生一般工业技术更多>>; 相关作者：徐芃更多>>; 相关机构：福州大学福建农林大学中国科学院福建物质结构研究所更多>>; 相关期刊：《Neural Regeneration Research》《Bioactive Materials》《Current Medical Science》《Chinese Chemical Letters》更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金更多>>

Resistance to antibody-drug conjugates:A review: 《Acta Pharmaceutica Sinica B》2025年第2期737-756,共20页Sijia Li Xinyu Zhao Kai Fu Shuangli Zhu Can Pan Chuan Yang Fang Wang Kenneth K.W.To Liwu Fu; supported by the National Natural Science Foundation of China(Nos.U21A20421 and 82073882);the Key Project of Science Technology Program of Guangzhou(No.2023B03J0029);Guangdong Basic and Applied Basic Research Foundation(No.2023B1515130009);Key-Area Research and Development Program of Guangdong Province(2023B1111020005).; Antibody-drug conjugates(ADCs)are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker.Currently,15 ADCs have been clinically approved worldwide.More than 100 clinical...; 关键词：Antibodyedrug conjugates Drug resistance Combination therapy Targeted therapy Cytotoxic therapy CANCER ONCOTHERAPY Predictive biomarker

Pretheranostic agents with extraordinary NIRF/photoacoustic imaging performance and photothermal oncotherapy efficacy: 《Acta Pharmaceutica Sinica B》2024年第12期5370-5381,共12页Liu Shi Zhenzhou Chen Jiaxin Ou En Liang Zhipeng Chen Qiuyue Fu Lan Huang Kui Cheng; supported by Foundation of Ministry of Science and Technology of China(2022YFC2304203);National Natural Science Foundation of China(Nos.82073689,82273762 and 81973183);National Natural Science Foundation of Guangdong Province(No.2024A1515010642,China);Science and Technology Program of Guangzhou(No.201904010380,China).; Cervical cancer,the most common gynecological malignancy,significantly and adversely af-fects women’s physical health and well-being.Traditional surgical interventions and chemotherapy,while potentially effective,oft...; 关键词：Biothiol detection Near-infrared fluorescence(NIRF)imaging Photoacoustic(PA)imaging Photothermal therapy(PTT) Cervical cancer

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy: 《Current Medical Science》2024年第2期261-272,共12页Meng-jie WANG Yu XIA Qing-lei GAO; DNA damage occurs across tumorigenesis and tumor development.Tumor intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orch...; 关键词：DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

Imaging-guided precision oncotherapy mediated by nanoprobes: From seeing to curing: 《Chinese Chemical Letters》2024年第1期116-128,共13页Jie Zheng Shi-Hui Chen Biao Huang Mingxi Zhang Quan Yuan Ran Cui; the National Key R&D Program of China(No.2020YFA0908800);the National Natural Science Foundation of China(Nos.22174105 and 21974104);Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.; Malignant tumors are the main diseases threatening human life. Using precise theranostics to diagnose and cure tumors has emerged as a new method to improve patient survival. Based on the current development of precis...; 关键词：Precise theranostics Imaging-guided Tumor surgical navigation Chemodynamic therapy Phototherapy NANOPROBES

From oncolytic peptides to oncolytic polymers:A new paradigm for oncotherapy: 《Bioactive Materials》2024年第1期206-230,共25页Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao; financially supported by National Natural Science Foundation of China[52203154 and 52222307];the Key Project of Anhui Provincial Department of Education[KJ2021A0543];Anhui University of Chinese Medicine Foundation[2022rcZD003 and 2022rczd010];the Major Fund Project of Anhui Provincial Department of Education[2022AH040077].; Traditional cancer therapy methods,especially those directed against specific intracellular targets or signaling pathways,are not powerful enough to overcome tumor heterogeneity and therapeutic resistance.Oncolytic pe...; 关键词：Oncolytic polymers Oncolytic peptides Cancer therapy Therapeutic resistance IMMUNOTHERAPY

Nanoplatform-based cellular reactive oxygen species regulation for enhanced oncotherapy and tumor resistance alleviation: 《Chinese Chemical Letters》2023年第9期85-99,共15页Meifang Wang Ping’an Ma Jun Lin; financially supported by the National Key Research and Development Program of China(No.2022YFB3804500);the National Natural Science Foundation of China(NSFC,Nos.51929201 and 52102354);the projects for Science and Technology Development Plan of Jilin province(Nos.20210402046GH and 20220508089RC)。; The cancer cells realize their proliferation and metastasis activities based on the special redox adaptation to increased reactive oxygen species(ROS)level,which inversely makes them sensitive to external interference...; 关键词：Nanoagents ROS regulation ROS-mediated cancer therapy Multidrug resistance THERMORESISTANCE

Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy被引量：2: 《Nano Research》2022年第6期5273-5278,共6页Mengyu Sun Yanjuan Sang Qingqing Deng Zhengwei Liu Jinsong Ren Xiaogang Qu; supported by the National Key R&D Program of China(No.2021YFF1200701);the National Natural Science Foundation of China(Nos.91856205,21820102009,and 21871249);the Key Program of Frontier of Sciences(No.CAS QYZDJ-SSW-SLH052)。; Nitric oxide(NO)gas therapy,especially,L-arginine(L-Arg)-based NO treatment strategies have attracted extensive attention in the field of oncotherapy.However,current strategies are unable to differentiate well between...; 关键词：nitric oxide nitric oxide synthetase nanozyme MITOCHONDRIA specific cancer therapy

Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy被引量：5: 《Bioactive Materials》2022年第3期590-601,共12页Chunhui Li Tongren Yang Yuhua Weng Mengjie Zhang Deyao Zhao Shuai Guo Bo Hu Wanxuan Shao Xiaoxia Wang Abid Hussain Xing-Jie Liang Yuanyu Huang; This work was supported by the Hu-Xiang Young Talent Program(2018RS3094);the Hunan Provincial Natural Science Foundation of China(2019JJ50196,2018JJ1019);the Natural Science Foundation of Guangdong Province(2019A1515010776);the National Natural Science Foundation of China(31901053,32001008,31871003);the Beijing Nova Program from Beijing Municipal Science&Technology Commission(Z201100006820005);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100);the National Key R&D Program of China(2019YFE0133300);the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology(2020-2022),and the Postdoctoral Science Foundation of China(2020M670169);We thank Biological&Medical Engineering Core Facilities(Beijing Institute of Technology)for providing advanced equipment.; CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool,that relies on Cas9 protein and single guided RNA(sgRNA)to edit target DNA.However,the lack of safe and efficient delivery carrier is one ...; 关键词：CRISPR/Cas Gene editing Lipid nanoparticle PLK1 Cancer therapy

BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy被引量：1: 《Nano Research》2022年第3期2235-2243,共9页Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong; National Natural Science Foundation(NNSF)of China(Nos.61775095,61935004,and 51803091);Jiangsu Province Policy Guidance Plan(No.BZ2019014);Natural Science Foundation of Jiangsu Province(No.BK20200092);Natural Science Foundation of Shandong Province(No.ZR2020KB018);“Taishan scholars”construction special fund of Shandong Province.; Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate.Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced ...; 关键词：chemotherapy chemodynamic therapy cascade therapy CDDP Fenton reaction

Nanomaterial-assisted sensitization of oncotherapy被引量：1: 《Nano Research》2018年第6期2932-2950,共19页Yufei Wang Juan Liu Xiaowei Ma Xing-Jie Liang; Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. Conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cance...; 关键词：NANOMATERIAL ONCOTHERAPY sensitization of oncotherapy mulfidrug resistance

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