Pretheranostic agents with extraordinary NIRF/photoacoustic imaging performance and photothermal oncotherapy efficacy  

作　　者：Liu Shi Zhenzhou Chen Jiaxin Ou En Liang Zhipeng Chen Qiuyue Fu Lan Huang Kui Cheng 

机构地区：[1]Guangdong Provincial Key Laboratory of New Drug Screening,NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China [2]State Key Laboratory of Organ Failure Research,Key Laboratory of Infectious Diseases Research in South China,Ministry of Education,Southern Medical University,Guangzhou 510515,China [3]Jieyang Medical Research Center,Jieyang People’s Hospital,Jieyang 522000,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第12期5370-5381,共12页药学学报（英文版）

基　　金：supported by Foundation of Ministry of Science and Technology of China(2022YFC2304203);National Natural Science Foundation of China(Nos.82073689,82273762 and 81973183);National Natural Science Foundation of Guangdong Province(No.2024A1515010642,China);Science and Technology Program of Guangzhou(No.201904010380,China).

摘　　要：Cervical cancer,the most common gynecological malignancy,significantly and adversely af-fects women’s physical health and well-being.Traditional surgical interventions and chemotherapy,while potentially effective,often entail serious side effects that have led to an urgent need for novel therapeutic methods.Photothermal therapy(PTT)has emerged as a promising approach due to its ability to minimize damage to healthy tissue.Connecting a biothiol detection group to PTT-sensitive molecules can improve tumor targeting and further minimize potential side effects.In this study,we developed a near-infrared fluorescence(NIRF)/photoacoustic(PA)dual-mode probe,S-NBD,which demonstrated robust PTT per-formance.This innovative probe is capable of activating NIRF/PA signals to enable the detection of bio-thiols with high emission wavelength(838 nm)and large Stokes shift(178 nm),allowing for in vivo monitoring of cancer cells.Additionally,the probe achieved an outstanding photothermal conversion ef-ficiency of 67.1%.The application of laser irradiation(660 nm,1.0 W/cm^(2),5 min)was able to achieve complete tumor ablation without recurrence.In summary,this seminal study presents a pioneering NIRF/PA dual-mode dicyanoisophorone-based probe for biothiol imaging,incorporating features from PTT for the first time.This pioneering approach achieves the dual objectives of improving tumor diagnosis and treatment.

关 键 词：Biothiol detection Near-infrared fluorescence(NIRF)imaging Photoacoustic(PA)imaging Photothermal therapy(PTT) Cervical cancer 

分 类 号：R730.5[医药卫生—肿瘤]