From oncolytic peptides to oncolytic polymers:A new paradigm for oncotherapy  

作　　者：Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao 

机构地区：[1]School of Pharmacy,Anhui University of Chinese Medicine,Hefei,230012,China [2]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China [3]Department of Orthopaedic Surgery,China-Japan Union Hospital,Jilin University,Changchun,130033,China [4]Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Hefei,Anhui,230012,China [5]Engineering Technology Research Center of Modernized Pharmaceutics,Anhui Education Department(AUCM),Hefei,Anhui,230012,China

出　　处：《Bioactive Materials》2024年第1期206-230,共25页生物活性材料（英文）

基　　金：financially supported by National Natural Science Foundation of China[52203154 and 52222307];the Key Project of Anhui Provincial Department of Education[KJ2021A0543];Anhui University of Chinese Medicine Foundation[2022rcZD003 and 2022rczd010];the Major Fund Project of Anhui Provincial Department of Education[2022AH040077].

摘　　要：Traditional cancer therapy methods,especially those directed against specific intracellular targets or signaling pathways,are not powerful enough to overcome tumor heterogeneity and therapeutic resistance.Oncolytic peptides that can induce membrane lysis-mediated cancer cell death and subsequent anticancer immune responses,has provided a new paradigm for cancer therapy.However,the clinical application of oncolytic peptides is always limited by some factors such as unsatisfactory bio-distribution,poor stability,and off-target toxicity.To overcome these limitations,oncolytic polymers stand out as prospective therapeutic materials owing to their high stability,chemical versatility,and scalable production capacity,which has the potential to drive a revolution in cancer treatment.This review provides an overview of the mechanism and structure-activity relationship of oncolytic peptides.Then the oncolytic peptides-mediated combination therapy and the nano-delivery strategies for oncolytic peptides are summarized.Emphatically,the current research progress of oncolytic polymers has been highlighted.Lastly,the challenges and prospects in the development of oncolytic polymers are discussed.

关 键 词：Oncolytic polymers Oncolytic peptides Cancer therapy Therapeutic resistance IMMUNOTHERAPY 

分 类 号：R730.5[医药卫生—肿瘤]